Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463477 | 0.84 | ITGA1 (0.37) | KMT2AMEN1MAP2K1TDP1KAT6A | |
| SCHEMBL7464207 | 0.84 | CCR6 (0.34) | KMT2AMEN1MAP2K1TDP1MAPT | |
| SCHEMBL7455817 | 0.83 | KDM4E (0.40) | KMT2AMEN1MAP2K1TDP1MAPT | |
| SCHEMBL7117133 | 0.82 | HDAC6 (0.35) | KMT2AMEN1MAP2K1TDP1 | |
| SCHEMBL7123741 | 0.81 | NAMPT (0.38) | MAP2K1 | |
| SCHEMBL7785868 | 0.79 | CXCR3 (0.34) | KMT2AMEN1TDP1TSHR | |
| SCHEMBL7118600 | 0.79 | JAK2 (0.40) | POLBALDH1A1TSHR | |
| SCHEMBL7115296 | 0.77 | JAK2 (0.38) | MAP2K1LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL7783692 | 0.77 | HDAC6 (0.37) | KMT2AMEN1TDP1 | |
| SCHEMBL7122977 | 0.77 | NAMPT (0.35) | MAP2K1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |