Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7116367 | 1.00 | MAPT (0.43) | MAPTNPC1RAB9AMAPK1HTT | |
| Hydrochloric Acid SCHEMBL7164469 | 0.99 | HTT (0.45) | MAPTNPC1RAB9AMAPK1HTT | |
| Hydrochloric Acid SCHEMBL7164464 | 0.99 | HTT (0.45) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL7122941 | 0.88 | NPC1 (0.45) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL7122947 | 0.88 | NPC1 (0.45) | MAPTNPC1RAB9AMAPK1HTT | |
| Hydrochloric Acid SCHEMBL7169681 | 0.87 | HTT (0.47) | MAPTNPC1RAB9AMAPK1HTT | |
| Hydrochloric Acid SCHEMBL7169684 | 0.87 | HTT (0.47) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL7116851 | 0.85 | HTT (0.44) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL7116856 | 0.85 | HTT (0.44) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL7116844 | 0.84 | NPC1 (0.44) | MAPTNPC1RAB9AMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653508-B2 | Use treating various medical conditions, including pain | GRUENENTHAL GMBH (DE) | 2003-11-25 | — | — | US | claimed |
| JP-2003505358-A | — | — | 2003-02-12 | — | — | JP | claimed |
| US-20020161262-A1 | 3-Amino-2-benzyl-1-phenylpropane derivatives | GRUENTENTHAL GMBH (DE) | 2002-10-31 | — | — | US | claimed |
| EP-1196373-A1 | 3-AMINO-2-BENZYL-1-PHENYL-PROPANE DERIVATIVES | Grünenthal GmbH (DE) | 2002-04-17 | — | — | EP | claimed |
| WO-2001005743-A1 | 3-AMINO-2-BENZYL-1-PHENYL-PROPANE DERIVATIVES | Grünenthal GmbH (DE) | 2001-01-25 | — | — | WO | claimed |
| US-6653508-B2 | Use treating various medical conditions, including pain | GRUENENTHAL GMBH (DE) | 2003-11-25 | — | — | US | disclosed |
| US-20020161262-A1 | 3-Amino-2-benzyl-1-phenylpropane derivatives | GRUENTENTHAL GMBH (DE) | 2002-10-31 | — | — | US | disclosed |
| EP-1196373-A1 | 3-AMINO-2-BENZYL-1-PHENYL-PROPANE DERIVATIVES | Grünenthal GmbH (DE) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005743-A1 | 3-AMINO-2-BENZYL-1-PHENYL-PROPANE DERIVATIVES | Grünenthal GmbH (DE) | 2001-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161262-A1 | 3-Amino-2-benzyl-1-phenylpropane derivatives | PYGL, CYP11B2, GOT2 | MAPT 1038/4885NPC1 11/4885RAB9A 1573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.