Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GRN | P28799 | 2/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | CLK2 | P49760 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17045543 | 0.83 | HSP90AA1 (0.37) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL432964 | 0.76 | KDM4E (0.50) | KDM4EPOLBGRNSORT1HSD17B10 | |
| SCHEMBL12859083 | 0.76 | NPC1 (0.39) | KDM4EPOLBHPGDSMN1; SMN2GRN | |
| SCHEMBL10156873 | 0.76 | GRN (0.37) | KDM4EPOLBGRNSORT1CSF1R | |
| SCHEMBL399615 | 0.76 | POLB (0.44) | KDM4EPOLBHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL21305805 | 0.74 | GRN (0.40) | KDM4EPOLBSMN1; SMN2GRNSORT1 | |
| SCHEMBL19433402 | 0.74 | SMN1; SMN2 (0.38) | KDM4EPOLBHPGDSMN1; SMN2RET | |
| SCHEMBL15472828 | 0.71 | CDK8 (0.51) | KDM4ESMN1; SMN2GRNSORT1CSF1R | |
| SCHEMBL12545850 | 0.71 | GRN (0.34) | KDM4EHPGDGRNSORT1LMNA | |
| SCHEMBL3843249 | 0.71 | KDM4E (0.46) | KDM4EPOLBSMN1; SMN2GRNSORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119490458-A | C-3 pyrazole substituted indazole derivative and application thereof | 沈阳药科大学 | 2025-02-21 | — | — | CN | disclosed |
| WO-2025035645-A1 | C-3 PYRAZOLE SUBSTITUTED INDAZOLE DERIVATIVE AND USE THEREOF | 沈阳药科大学 | 2025-02-20 | — | — | WO | disclosed |
| US-11560391-B2 | Sulfonylurea compounds as inhibitors of interleukin-1 activity | GENENTECH, INC. (US) | 2023-01-24 | — | — | US | disclosed |
| US-11560391-B2 | Sulfonylurea compounds as inhibitors of interleukin-1 activity | GENENTECH, INC. (US) | 2023-01-24 | — | — | US | disclosed |
| EP-3823726-A1 | SULFONYLUREA COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | F. Hoffmann-La Roche SA (CH) | 2021-05-26 | — | — | EP | disclosed |
| CN-112437683-A | Sulfonylurea compounds useful as inhibitors of interleukin-1 activity | 豪夫迈·罗氏有限公司 | 2021-03-02 | — | — | CN | disclosed |
| WO-2020018970-A1 | SULFONYLUREA COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | GENENTECH, INC. (US) | 2020-01-23 | — | — | WO | disclosed |
| WO-2020018970-A1 | SULFONYLUREA COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | GENENTECH, INC. (US) | 2020-01-23 | — | — | WO | disclosed |
| US-9771353-B2 | Kinase inhibitors based upon N-alkyl pyrazoles | TOPIVERT PHARMA LIMITED (GB) | 2017-09-26 | — | — | US | disclosed |
| EP-2981534-B1 | KINASE INHIBITORS BASED UPON N-ALKYL PYRAZOLES | TOPIVERT PHARMA LTD (GB) | 2017-07-19 | — | — | EP | disclosed |
| US-20070287838-A1 | Imidazo[4,5-B]Pyridin-2-One and Oxazolo[4,5-B]Pyridin-2-One Compounds and Analogs Thereof as Therapeutic Compounds | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-12-13 | — | — | US | disclosed |
| US-20070197624-A1 | Acylated amino acid amidyl pyrazoles and related compounds | ELAN PHARMACEUTICALS, INC. (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070197624-A1 | Acylated amino acid amidyl pyrazoles and related compounds | ELAN PHARMACEUTICALS, INC. (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070010548-A1 | Compounds having inhibitive activity of phosphatidylinositol 3-kinase and methods of use thereof | ZENTARIS GMBH (DE) | 2007-01-11 | — | — | US | disclosed |
| US-20070010548-A1 | Compounds having inhibitive activity of phosphatidylinositol 3-kinase and methods of use thereof | ZENTARIS GMBH (DE) | 2007-01-11 | — | — | US | disclosed |
| US-20070010548-A1 | Compounds having inhibitive activity of phosphatidylinositol 3-kinase and methods of use thereof | ZENTARIS GMBH (DE) | 2007-01-11 | — | — | US | disclosed |
| EP-1648463-A2 | COMPOUNDS HAVING INHIBITIVE ACTIVITY OF PHOSPHATIDYLINOSITOL 3-KINASE AND METHODS OF USE THEREOF | Zentaris GmbH (DE) | 2006-04-26 | — | — | EP | disclosed |
| EP-1633350-A2 | ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2005016245-A2 | COMPOUNDS HAVING INHIBITIVE ACTIVITY OF PHOSPHATIDYLINOSITOL 3-KINASE AND METHODS OF USE THEREOF | ZENTARIS GMBH (DE) | 2005-02-24 | — | — | WO | disclosed |
| WO-2005009344-A2 | ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS | ELAN PHARMACEUTICALS, INC. (US) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197624-A1 | Acylated amino acid amidyl pyrazoles and related compounds | APP, BACE1, APH1A | KDM4E 3673/4885POLB 4429/4885HPGD 1737/4885 |
| US-11560391-B2 | Sulfonylurea compounds as inhibitors of interleukin-1 activity | IL1B, IL1A, IL18 | KDM4E 4310/4885POLB 4762/4885HPGD 2797/4885 |
| US-20070010548-A1 | Compounds having inhibitive activity of phosphatidylinositol 3-kinase and methods of use thereof | IPMK, PI4KB, PDPK1 | KDM4E 2220/4885POLB 2356/4885HPGD 1340/4885 |
| US-20070287838-A1 | Imidazo[4,5-B]Pyridin-2-One and Oxazolo[4,5-B]Pyridin-2-One Compounds and Analogs Thereof as Therapeutic Compounds | NR2E1, NR0B1, BRAF | KDM4E 1292/4885POLB 765/4885HPGD 2497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.