Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733622 | 0.76 | ALDH1A1 (0.41) | POLBCYP1A2SMN1; SMN2HPGDLMNA | |
| SCHEMBL711746 | 0.76 | KDM4E (0.49) | POLBSMN1; SMN2HPGDLMNAKDM4E | |
| SCHEMBL21720000 | 0.73 | GAA (0.41) | POLBSMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL21718652 | 0.73 | ATM (0.39) | POLBCYP1A2SMN1; SMN2HPGDLMNA | |
| SCHEMBL21719846 | 0.73 | ATM (0.39) | POLBCYP1A2SMN1; SMN2HPGDKDM4E | |
| SCHEMBL21720660 | 0.73 | ATM (0.39) | POLBCYP1A2SMN1; SMN2HPGDKDM4E | |
| SCHEMBL9607537 | 0.73 | ATM (0.39) | POLBCYP1A2SMN1; SMN2HPGDKDM4E | |
| SCHEMBL12462469 | 0.73 | GAA (0.43) | POLBCYP1A2SMN1; SMN2HPGDLMNA | |
| SCHEMBL3661525 | 0.71 | SMN1; SMN2 (0.58) | POLBCYP1A2CYP2C19SMN1; SMN2HPGD | |
| SCHEMBL21166026 | 0.71 | POLB (0.44) | POLBCYP1A2MAPK1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122005693-A | Application of Jiaweidanzhi Xiaoyao powder or extract thereof in preparation of medicines for treating depression complicated with ulcerative colitis | 河南中医药大学 | 2026-05-12 | — | — | CN | claimed |
| CN-122005693-A | Application of Jiaweidanzhi Xiaoyao powder or extract thereof in preparation of medicines for treating depression complicated with ulcerative colitis | 河南中医药大学 | 2026-05-12 | — | — | CN | disclosed |
| US-20240376075-A1 | POLYMORPHIC FORMS OF AURORA A SELECTIVE INHIBITORS AND USES THEREOF | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-11-14 | — | — | US | disclosed |
| CN-118084890-A | Isoxazoline-containing pyrazole amide compound as well as preparation method and application thereof | 安徽农业大学 | 2024-05-28 | — | — | CN | disclosed |
| CN-117836285-A | Polymorphic forms of AURORA a selective inhibitor and uses thereof | 北京加科思新药研发有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-116354936-A | Novel heterocyclic compounds useful as selective AURORA a inhibitors | 北京加科思新药研发有限公司 | 2023-06-30 | — | — | CN | disclosed |
| US-20230128198-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD (CN) | 2023-04-27 | — | — | US | disclosed |
| CN-114423751-B | Novel heterocyclic compounds useful as selective AURORA a inhibitors | 北京加科思新药研发有限公司 | 2023-04-21 | — | — | CN | disclosed |
| WO-2023005957-A1 | POLYMORPHIC FORMS OF AURORA A SELECTIVE INHIBITORS AND USES THEREOF | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2023-02-02 | — | — | WO | disclosed |
| EP-4093736-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | Jacobio Pharmaceuticals Co., Ltd. (CN) | 2022-11-30 | — | — | EP | disclosed |
| US-20060089359-A1 | Phthalazinone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-27 | — | — | US | disclosed |
| WO-2006032518-A1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-30 | — | — | WO | disclosed |
| US-6645258-B2 | Oxidation base selected from a 3-substituted 4,5-diaminopyrazoles; reacting | L'OREAL, S.A. (FR) | 2003-11-11 | — | — | US | disclosed |
| US-20030019051-A9 | Composition for dyeing keratin fibers which contain at least one diaminopyrazole, dyeing process, novel diaminopyrazoles and process for their preparation | L'OREAL | 2003-01-30 | — | — | US | disclosed |
| US-20020050013-A1 | Composition for dyeing keratin fibers which contain at least one diaminopyrazole, dyeing process, novel diaminopyrazoles and process for their preparation | L'OREAL | 2002-05-02 | — | — | US | disclosed |
| US-6338741-B1 | 3-SUBSTITUTED 4,5-DIAMINOPYRAZOLES, OXIDATION HAIR DYES, STRONG COLORATION IN SHADES RANGING FROM RED TO BLUE | L'OREAL (FR) | 2002-01-15 | — | — | US | disclosed |
| US-6099592-A | SPECIFIED 3-SUBSTITUTED 4,5-DIAMINOPYRAZOLES SUCH AS 1-BENZYL-4,5-DIAMINO-3-METHYLPYRAZOLE AS OXIDATION DYE PRECURSORS; USE TO OBTAIN DYE COMPOSITIONS LEADING TO STRONG COLORATIONS, IN SHADES RANGING FROM RED TO BLUE | L'OREAL (FR) | 2000-08-08 | — | — | US | disclosed |
| EP-0389189-B1 | Diazepine antiallergy agents | PFIZER LTD (GB) | 1994-05-18 | — | — | EP | disclosed |
| US-5008263-A | Platelet activating factor antagonists; antiallergens; antiinflammatory agents | PFIZER INC. (US) | 1991-04-16 | — | — | US | disclosed |
| EP-0389189-A2 | Diazepine antiallergy agents | Pfizer Limited (GB) | 1990-09-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089359-A1 | Phthalazinone derivatives | SDHA, SDHB, CYP3A5 | POLB 819/4885CYP1A2 151/4885CYP2C19 34/4885 |
| US-20020050013-A1 | Composition for dyeing keratin fibers which contain at least one diaminopyrazole, dyeing process, novel diaminopyrazoles and process for their preparation | KRT18, DSP, TUBB3 | POLB 909/4885CYP1A2 928/4885CYP2C19 1890/4885 |
| US-20030019051-A9 | Composition for dyeing keratin fibers which contain at least one diaminopyrazole, dyeing process, novel diaminopyrazoles and process for their preparation | KRT18, DSP, TUBB3 | POLB 909/4885CYP1A2 928/4885CYP2C19 1890/4885 |
| US-20240376075-A1 | POLYMORPHIC FORMS OF AURORA A SELECTIVE INHIBITORS AND USES THEREOF | AURKA, AURKC, AURKB | POLB 495/4885CYP1A2 2383/4885CYP2C19 1689/4885 |
| US-20230128198-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | AURKA, AURKC, AURKB | POLB 2327/4885CYP1A2 3840/4885CYP2C19 3811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.