Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 10/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 11/20 | 0.41 |
| ▸ | RAB9A | P51151 | 11/20 | 0.41 |
| ▸ | SENP5 | Q96HI0 | 3/20 | 0.40 |
| ▸ | SENP2 | Q9HC62 | 3/20 | 0.40 |
| ▸ | SENP1 | Q9P0U3 | 3/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10372782 | 0.85 | F10 (0.46) | CXCR2MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL9249134 | 0.82 | MPO (0.50) | MAPTALDH1A1CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL8225601 | 0.79 | NPC1 (0.43) | MAPTALDH1A1CYP1A2CYP2C19NPC1 | |
| SCHEMBL10815290 | 0.77 | NPC1 (0.62) | MAPTALDH1A1CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL10372978 | 0.76 | MPO (0.52) | MAPTALDH1A1CYP1A2NPC1RAB9A | |
| SCHEMBL4651635 | 0.76 | LMNA (0.55) | CXCR2MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL4651710 | 0.75 | CXCR2 (0.51) | CXCR2MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL4652888 | 0.75 | CXCR2 (0.51) | CXCR2MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL4651616 | 0.75 | CXCR2 (0.51) | CXCR2MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL4650948 | 0.75 | PLK1 (0.60) | CXCR2MAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765668-B1 | Extract of Iridaceas and compositions containing it | OREAL (FR) | 1999-03-17 | — | — | EP | claimed |
| EP-0761204-B1 | Use of extracts of filamentous, non photosynthetic bacteria and the composition containing them | OREAL (FR) | 1998-04-15 | — | — | EP | claimed |
| EP-0765668-A1 | Extract of Iridaceas and composition containing it | L'OREAL (FR) | 1997-04-02 | — | — | EP | claimed |
| EP-0761204-A1 | Use of extracts of filamentous, non photosynthetic bacteria and the composition containing them | L'OREAL (FR) | 1997-03-12 | — | — | EP | claimed |
| EP-0729750-B1 | Alpha-TNF antagonists in a cosmetic, pharmaceutical or dermatological composition. | OREAL (FR) | 2004-03-24 | — | — | EP | disclosed |
| EP-0717997-B1 | Use of substance P antagonist in pharmaceutical composition | OREAL (FR) | 2001-08-16 | — | — | EP | disclosed |
| EP-0722736-B1 | Topical composition containing an antagonist of substance P | OREAL (FR) | 2001-01-31 | — | — | EP | disclosed |
| US-6146636-A | ADMINISTERING A PATIENT FOR TREATMENT OF A DISEASE STATE, DISORDER, CONDITION OR AFFLICTION ENTAILING AN EXCESSIVE SYNTHESIS OR RELEASE OF SUBSTANCE P, AN EFFECTIVE AMOUNT OF ROSACEAE FAMILY PLANT EXTRACT AS SUBSTANCE P ANTAGONIST | SOCIETE L'OREAL S.A. (FR) | 2000-11-14 | — | — | US | disclosed |
| US-5972892-A | FOR REDUCING OR ELIMINATING THE SKIN IRRITANT SIDE-EFFECT OF A THERAPEUTIC COMPOSITION; A STABILIZER FOR DESENSITIZATION | L'OREAL (FR) | 1999-10-26 | — | — | US | disclosed |
| US-5824650-A | ANTIINFLAMMATORY AGENTS FOR SKIN BY APPLYING TOPICALLY SUBSTANCE P ANTAGONIST | L'OREAL (FR) | 1998-10-20 | — | — | US | disclosed |
| US-5744156-A | TOPICALLY APPLYING COMPOSITION CONTAINING SUBSTANCE P ANTAGONIST TO TREAT ROSACEA, PUDIC ERYTHEMA | SOCIETE L'OREAL S.A. (FR) | 1998-04-28 | — | — | US | disclosed |
| EP-0729750-A1 | Use of an interleukin-1 antagonist and/or alpha-TNF antagonist in a cosmetic, pharmaceutical or dermatological composition, and the composition therefrom, possibly used in combination with a histamine antagonist | L'OREAL (FR) | 1996-09-04 | — | — | EP | disclosed |
| EP-0722736-A1 | Topical composition containing an antagonist of substance P | L'OREAL (FR) | 1996-07-24 | — | — | EP | disclosed |
| EP-0717997-A1 | Use of substance P antagonist in pharmaceutical composition | L'OREAL (FR) | 1996-06-26 | — | — | EP | disclosed |