Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.43 |
| ▸ | RAB9A | P51151 | 9/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10371933 | 0.83 | CYSLTR2 (0.38) | — | |
| SCHEMBL7121515 | 0.79 | CXCR2 (0.44) | NPC1RAB9ASMN1; SMN2TP53KMT2A | |
| SCHEMBL10372061 | 0.78 | FGFR1 (0.40) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL10372228 | 0.76 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2TP53ATM | |
| SCHEMBL10374209 | 0.76 | CYSLTR2 (0.36) | KDM4EHSD17B10 | |
| SCHEMBL10371019 | 0.76 | TSHR (0.54) | NPC1RAB9ASMN1; SMN2TP53ATM | |
| SCHEMBL9248201 | 0.74 | KMT2A (0.41) | NPC1RAB9ASMN1; SMN2TP53ATM | |
| SCHEMBL10371010 | 0.74 | ALDH1A1 (0.38) | SMN1; SMN2TP53KMT2ALMNAKDM4E | |
| SCHEMBL10372173 | 0.74 | NPC1 (0.42) | NPC1RAB9AATMKMT2AKDM4E | |
| SCHEMBL10371048 | 0.74 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2ATMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6146636-A | ADMINISTERING A PATIENT FOR TREATMENT OF A DISEASE STATE, DISORDER, CONDITION OR AFFLICTION ENTAILING AN EXCESSIVE SYNTHESIS OR RELEASE OF SUBSTANCE P, AN EFFECTIVE AMOUNT OF ROSACEAE FAMILY PLANT EXTRACT AS SUBSTANCE P ANTAGONIST | SOCIETE L'OREAL S.A. (FR) | 2000-11-14 | — | — | US | disclosed |