Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 1/20 | 0.60 |
| ▸ | LPAR3 | Q9UBY5 | 9/20 | 0.62 |
| ▸ | LPAR2 | Q9HBW0 | 7/20 | 0.62 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.62 |
| ▸ | CDC25A | P30304 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | ESR1 | P03372 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | AKT1 | P31749 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FABP3 | P05413 | 3/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29663701 | 0.96 | LPAR3 (0.62) | LPAR3LPAR2LPAR1CDC25ALMNA | |
| SCHEMBL7864946 | 0.96 | LPAR3 (0.62) | LPAR3LPAR2LPAR1CDC25ALMNA | |
| SCHEMBL7872460 | 0.96 | LPAR3 (0.62) | LPAR3LPAR2LPAR1CDC25ALMNA | |
| SCHEMBL29510011 | 0.96 | LPAR3 (0.62) | LPAR3LPAR2LPAR1CDC25ALMNA | |
| SCHEMBL29496479 | 0.96 | LPAR3 (0.62) | LPAR3LPAR2LPAR1CDC25ALMNA | |
| SCHEMBL4817480 | 0.96 | LPAR3 (0.62) | LPAR3LPAR2LPAR1CDC25ALMNA | |
| SCHEMBL8374141 | 0.92 | LPAR3 (0.58) | LPAR3LPAR2LPAR1CDC25ALMNA | |
| SCHEMBL8374140 | 0.92 | LPAR3 (0.58) | LPAR3LPAR2LPAR1CDC25ALMNA | |
| Potassium Ion SCHEMBL2046315 | 0.89 | LPAR3 (0.62) | LPAR3LPAR2LPAR1CDC25ALMNA | |
| Potassium Ion SCHEMBL2046322 | 0.89 | LPAR3 (0.62) | LPAR3LPAR2LPAR1CDC25ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785247-B1 | REFRIGERATOR OIL COMPOSITION | IDEMITSU KOSAN CO (JP) | 2003-11-19 | — | — | EP | claimed |