Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 3/20 | 0.59 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.50 |
| ▸ | SCN1A | P35498 | 3/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.50 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL712317 | 0.80 | SCN9A (0.60) | SCN9ASCN3ASCN1ASCN5ASCN8A | |
| SCHEMBL15212145 | 0.77 | PKM (0.64) | ALPLSCN9AUSP2MAPTESR2 | |
| SCHEMBL714370 | 0.77 | MEN1 (0.44) | SCN9ASCN3ASCN1ASCN5ASCN8A | |
| SCHEMBL713884 | 0.75 | SCN9A (0.52) | SCN9ASCN1ASCN5ASCN8AUSP2 | |
| SCHEMBL4173014 | 0.75 | SCN9A (0.66) | SCN9ASCN3ASCN1ASCN5ASCN8A | |
| SCHEMBL3018907 | 0.74 | ALPL (0.58) | ALPLPPARGHSD17B1HSD17B2ADRA2A | |
| SCHEMBL22252121 | 0.73 | ALPL (0.61) | ALPLPPARGHSD17B1HSD17B2ADRA2A | |
| SCHEMBL3019244 | 0.73 | ALPL (0.57) | ALPLPPARGHSD17B1HSD17B2ADRA2A | |
| SCHEMBL26530281 | 0.73 | SCN3A (0.71) | SCN9ASCN3ASCN5AMEN1ALDH1A1 | |
| SCHEMBL709771 | 0.72 | SCN9A (0.52) | SCN9ASCN3ASCN1ASCN5ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124610-B2 | Sodium channel inhibitors | ICAGEN INC. (US) | 2012-02-28 | — | — | US | disclosed |
| US-8124610-B2 | Sodium channel inhibitors | ICAGEN INC. (US) | 2012-02-28 | — | — | US | disclosed |
| EP-2173743-A2 | SODIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| US-20090023740-A1 | SODIUM CHANNEL INHIBITORS | ICAGEN (US) | 2009-01-22 | — | — | US | disclosed |
| US-20090023740-A1 | SODIUM CHANNEL INHIBITORS | ICAGEN (US) | 2009-01-22 | — | — | US | disclosed |
| WO-2009012242-A2 | SODIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 2009-01-22 | — | — | WO | disclosed |
| WO-2009012242-A2 | SODIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023740-A1 | SODIUM CHANNEL INHIBITORS | TRPV1, SCN1A, SCN2A | ALPL 4043/4885SCN9A 17/4885SCN3A 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.