Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.58 |
| ▸ | IDH1 | O75874 | 19/20 | 0.55 |
| ▸ | IDH2 | P48735 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30064571 | 0.87 | IDH1 (0.56) | DAOIDH1IDH2 | |
| SCHEMBL17603372 | 0.87 | DAO (0.59) | DAOIDH1 | |
| SCHEMBL30064597 | 0.87 | IDH1 (0.56) | DAOIDH1IDH2 | |
| SCHEMBL17601343 | 0.87 | IDH1 (0.56) | DAOIDH1IDH2 | |
| SCHEMBL17601233 | 0.87 | IDH1 (0.56) | DAOIDH1IDH2 | |
| SCHEMBL17601235 | 0.87 | IDH1 (0.56) | DAOIDH1IDH2 | |
| SCHEMBL17615959 | 0.86 | IDH1 (0.61) | IDH1IDH2 | |
| Hydrochloric Acid SCHEMBL17601514 | 0.86 | IDH1 (0.55) | DAOIDH1IDH2 | |
| Hydrochloric Acid SCHEMBL17601506 | 0.86 | IDH1 (0.55) | DAOIDH1IDH2 | |
| SCHEMBL17615974 | 0.86 | IDH1 (0.61) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4257131-A2 | PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2023-10-11 | — | — | EP | disclosed |
| EP-4215197-A1 | INHIBITING MUTANT IDH-1 | Forma Therapeutics, Inc. (US) | 2023-07-26 | — | — | EP | disclosed |
| EP-3733662-B1 | PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS INC (US) | 2023-06-07 | — | — | EP | disclosed |
| US-20230066088-A1 | INHIBITING MUTANT ISOCITRATE DEHYDROGENASE 1 (mIDH-1) | FORMA THERAPEUTICS, INC. | 2023-03-02 | — | — | US | disclosed |
| EP-3720442-B1 | INHIBITING MUTANT IDH-1 | FORMA THERAPEUTICS INC (US) | 2022-12-28 | — | — | EP | disclosed |
| US-11311527-B2 | Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1) | FORMA THERAPEUTICS, INC. (US) | 2022-04-26 | — | — | US | disclosed |
| US-20210244727-A1 | INHIBITING MUTANT ISOCITRATE DEHYDROGENASE 1 (mIDH-1) | FORMA THERAPEUTICS, INC. | 2021-08-12 | — | — | US | disclosed |
| US-20210196701-A1 | INHIBITING MUTANT IDH-1 | FORMA THERAPEUTICS, INC. | 2021-07-01 | — | — | US | disclosed |
| US-11013733-B2 | Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1) | FORMA THERAPEUTICS, INC. (US) | 2021-05-25 | — | — | US | disclosed |
| EP-3733662-A1 | PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |
| EP-3447050-B1 | PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS INC (US) | 2020-02-19 | — | — | EP | disclosed |
| US-20190350921-A1 | INHIBITING MUTANT ISOCITRATE DEHYDROGENASE 1 (mIDH-1) | FORMA THERAPEUTICS, INC. (US) | 2019-11-21 | — | — | US | disclosed |
| EP-3194383-B1 | QUINOLINONE PYRIMIDINES COMPOSITIONS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS INC (US) | 2019-11-06 | — | — | EP | disclosed |
| US-10005734-B2 | Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors | FORMA THERAPEUTICS, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-9834539-B2 | Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors | FORMA THERAPEUTICS, INC. (US) | 2017-12-05 | — | — | US | disclosed |
| US-20170174658-A1 | PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. | 2017-06-22 | — | — | US | disclosed |
| US-20160083366-A1 | PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. | 2016-03-24 | — | — | US | disclosed |
| US-20030069271-A1 | Quinolone compounds for use in treating viral infections | SMITHKLINE BEECHAM CORPORATION | 2003-04-10 | — | — | US | disclosed |
| EP-1244629-A2 | QUINOLONE COMPOUNDS FOR USE IN TREATING VIRAL INFECTIONS | GLAXO GROUP LIMITED (GB) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001046150-A2 | QUINOLONE COMPOUNDS FOR USE IN TREATING VIRAL INFECTIONS | GLAXO GROUP LIMITED (GB) | 2001-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10005734-B2 | Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors | IDH3A, IDH1, IDH2 | DAO 1197/4885IDH1 2/4885IDH2 3/4885 |
| US-20210196701-A1 | INHIBITING MUTANT IDH-1 | IDH3A, IDH3B, IDH1 | DAO 3150/4885IDH1 3/4885IDH2 4/4885 |
| US-20170174658-A1 | PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | IDH1, IDH3A, IDH2 | DAO 871/4885IDH1 1/4885IDH2 3/4885 |
| US-20030069271-A1 | Quinolone compounds for use in treating viral infections | IRF3, MAVS, NQO2 | DAO 1780/4885IDH1 1072/4885IDH2 584/4885 |
| US-20210244727-A1 | INHIBITING MUTANT ISOCITRATE DEHYDROGENASE 1 (mIDH-1) | IDH1, IDH3B, IDH2 | DAO 2078/4885IDH1 1/4885IDH2 3/4885 |
| US-11013733-B2 | Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1) | MDH1, IDH1, MDH2 | DAO 1793/4885IDH1 2/4885IDH2 4/4885 |
| US-11311527-B2 | Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1) | IDH1, IDH3B, IDH2 | DAO 2078/4885IDH1 1/4885IDH2 3/4885 |
| US-20230066088-A1 | INHIBITING MUTANT ISOCITRATE DEHYDROGENASE 1 (mIDH-1) | IDH1, IDH3B, IDH2 | DAO 2078/4885IDH1 1/4885IDH2 3/4885 |
| US-20160083366-A1 | PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | IDH1, IDH3A, IDH2 | DAO 871/4885IDH1 1/4885IDH2 3/4885 |
| US-20190350921-A1 | INHIBITING MUTANT ISOCITRATE DEHYDROGENASE 1 (mIDH-1) | IDH1, IDH3B, IDH2 | DAO 2078/4885IDH1 1/4885IDH2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.