Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 4/20 | 0.38 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496082 | 0.95 | KCNH2 (0.48) | KCNH2MEN1KMT2AMAPTUSP2 | |
| SCHEMBL6218398 | 0.83 | KCNH2 (0.49) | KCNH2MAPTALOX15TDP1ADRB2 | |
| SCHEMBL2081998 | 0.83 | ADRB2 (0.45) | KCNH2MEN1KMT2AMAPTUSP2 | |
| SCHEMBL5733629 | 0.83 | ADRB2 (0.48) | KCNH2MEN1KMT2AMAPTALOX15 | |
| SCHEMBL116273 | 0.82 | ADRB2 (0.52) | KCNH2MEN1KMT2AALOX15TDP1 | |
| SCHEMBL7504273 | 0.81 | ADRB2 (0.47) | KCNH2MEN1KMT2AMAPTTDP1 | |
| SCHEMBL7507103 | 0.81 | ADRB2 (0.55) | KCNH2KMT2ATDP1ADRB2LMNA | |
| SCHEMBL1342473 | 0.80 | ADRB2 (0.56) | KCNH2MEN1KMT2AALOX15TDP1 | |
| SCHEMBL6220868 | 0.79 | KCNH2 (0.46) | KCNH2MAPTALOX15TDP1ADRB2 | |
| SCHEMBL7500713 | 0.79 | ADRB2 (0.47) | KCNH2MEN1KMT2AMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| US-5763450-A | BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |