Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyamine SCHEMBL7974827 | 0.80 | KMT2A (0.52) | IDO1CES2CES1AKR1B1GAA | |
| SCHEMBL23891955 | 0.80 | LOXL2 (0.48) | NOS1HDAC6NOS3NOS2TAAR1 | |
| SCHEMBL434982 | 0.79 | HDAC8 (0.56) | IDO1CES2CES1AKR1B1GAA | |
| SCHEMBL12875618 | 0.78 | IDO1 (0.47) | IDO1GAAKMT2AMEN1MAPT | |
| SCHEMBL2643808 | 0.77 | CES1 (0.44) | IDO1CES2CES1AKR1B1NOS1 | |
| SCHEMBL24027026 | 0.77 | CES2 (0.44) | IDO1CES2CES1AKR1B1NOS1 | |
| SCHEMBL6831173 | 0.76 | ALDH1A1 (0.54) | IDO1GAAKMT2AMEN1MAPT | |
| SCHEMBL10945140 | 0.76 | EPHX2 (0.59) | CES2CES1AKR1B1GAAKMT2A | |
| Hydrochloric Acid SCHEMBL4737686 | 0.74 | ALDH1A1 (0.52) | IDO1GAAKMT2AMEN1CYP3A4 | |
| SCHEMBL1238345 | 0.73 | HTR3E (0.57) | IDO1CES2CES1AKR1B1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022005898-A1 | RIP1K INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| US-20130243754-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | TARGEGEN, INC. (US) | 2013-09-19 | — | — | US | disclosed |
| US-8372971-B2 | Heterocyclic compounds and methods of use | TARGEGEN, INC. (US) | 2013-02-12 | — | — | US | disclosed |
| US-20120220584-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | TARGEGEN, INC. (US) | 2012-08-30 | — | — | US | disclosed |
| US-6667356-B2 | Including an n-amidinobenzamide derivative; heat aging resistance | BRIDGESTONE CORPORATION (JP) | 2003-12-23 | — | — | US | disclosed |
| US-20030134947-A1 | Containing imine, amidine or guanidine antioxidants to improve heat aging resistance; may be substituted by acyl, thioacyl or additional imine groups | BRIDGESTONE CORPORATION, OTSUKA CHEMICAL CO., LTD. | 2003-07-17 | — | — | US | disclosed |
| US-6515055-B1 | Excellent in heat aging resistance due to addition of compounds exemplified by N'-(N-benzoylamidino) benzoic acid hydrazide | BRIDGESTONE CORPORATION (JP) | 2003-02-04 | — | — | US | disclosed |
| EP-1101793-A1 | Heat ageing resistant rubber composition | Bridgestone Corporation (JP) | 2001-05-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220584-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AADAC, NISCH, PAICS | IDO1 1066/4885CES2 337/4885CES1 2714/4885 |
| US-20130243754-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AADAC, NISCH, PAICS | IDO1 1066/4885CES2 337/4885CES1 2714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.