SCHEMBL7123540

SCHEMBL7123540

N#Cc1ccc(OCc2ccccc2)c(CC(=O)Nc2ccc(C(=O)N3CCCC3)c(Cl)c2)c1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.49
POLB P06746 1/20 0.49
P2RX4 Q99571 1/20 0.47
MET P08581 3/20 0.46
SLC6A9 P48067 1/20 0.43
NPY2R P49146 1/20 0.43
LMNA P02545 1/20 0.42
MRGPRX4 Q96LA9 2/20 0.42
ACP1 P24666 1/20 0.40
PTPN12 Q05209 1/20 0.40
PTPN13 Q12923 1/20 0.40
SSU72 Q9NP77 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
PPIA P62937 1/20 0.40
TRPM4 Q8TD43 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7113075 0.90 MET (0.46) HPGDP2RX4METSLC6A9LMNA
SCHEMBL5099764 0.90 MET (0.46) P2RX4METSLC6A9LMNAMRGPRX4
SCHEMBL7126958 0.89 MET (0.46) P2RX4METSLC6A9LMNANPC1
SCHEMBL7124454 0.88 MET (0.45) P2RX4METSLC6A9LMNAMRGPRX4
SCHEMBL6554651 0.84 HPGD (0.45) HPGDMETSLC6A9MRGPRX4NPC1
SCHEMBL5093181 0.82 SLC6A9 (0.45) METSLC6A9MRGPRX4NPC1RAB9A
SCHEMBL7127088 0.79 MRGPRX4 (0.49) P2RX4METLMNAMRGPRX4PPIA
SCHEMBL7121876 0.79 ALDH1A1 (0.49) P2RX4LMNA
SCHEMBL7117549 0.77 SPHK1 (0.47) P2RX4METLMNAMRGPRX4
SCHEMBL7160217 0.77 P2RX4 (0.44) HPGDP2RX4METNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1360170-A1 CARBOXYLIC AMIDES, THE PRODUCTION AND USE THEREOF AS MEDICAMENTS Boehringer Ingelheim Pharma GmbH & Co.KG (DE) 2003-11-12 EP disclosed
US-20020151595-A1 Carboxylic acid amides having antithrombotic activity BOEHRINGER INGELHEIM PHARMA KG (DE) 2002-10-17 US disclosed
WO-2002062748-A1 CARBOXYLIC AMIDES, THE PRODUCTION AND USE THEREOF AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2002-08-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020151595-A1 Carboxylic acid amides having antithrombotic activity SERPINC1, TFPI, F2 HPGD 1175/4885POLB 3255/4885P2RX4 2133/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.