Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.80 |
| ▸ | HPGD | P15428 | 5/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.80 |
| ▸ | RECQL | P46063 | 2/20 | 0.80 |
| ▸ | USP2 | O75604 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 6/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.75 |
| ▸ | TNKS | O95271 | 4/20 | 0.75 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.75 |
| ▸ | PARP1 | P09874 | 2/20 | 0.75 |
| ▸ | TP53 | P04637 | 5/20 | 0.74 |
| ▸ | MAPT | P10636 | 5/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.74 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650072 | 0.91 | CYP3A4 (0.82) | CYP3A4ALDH1A1HPGDKDM4EMAPK1 | |
| 7,3'-Dimethoxyflavone SCHEMBL718068 | 0.89 | KDM4E (1.00) | CYP3A4ALDH1A1HPGDKDM4EMAPK1 | |
| SCHEMBL31675776 | 0.86 | CYP3A4 (1.00) | CYP3A4ALDH1A1HPGDKDM4EMAPK1 | |
| SCHEMBL3135989 | 0.86 | CYP3A4 (1.00) | CYP3A4ALDH1A1HPGDKDM4EMAPK1 | |
| SCHEMBL312254 | 0.85 | CYP3A4 (1.00) | CYP3A4ALDH1A1HPGDKDM4EMAPK1 | |
| SCHEMBL30266579 | 0.85 | CYP3A4 (1.00) | CYP3A4ALDH1A1HPGDKDM4EMAPK1 | |
| 7-Methoxyflavone SCHEMBL1373009 | 0.85 | TNKS (1.00) | CYP3A4ALDH1A1HPGDKDM4EMAPK1 | |
| SCHEMBL534596 | 0.84 | CYP3A4 (1.00) | CYP3A4ALDH1A1HPGDKDM4EMAPK1 | |
| SCHEMBL30120666 | 0.84 | CYP3A4 (1.00) | CYP3A4ALDH1A1HPGDKDM4EMAPK1 | |
| SCHEMBL4649870 | 0.83 | MAPT (1.00) | CYP3A4ALDH1A1HPGDKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003504327-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1223928-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | Prendergast, Patrick Thomas (IE) | 2002-07-24 | — | — | EP | claimed |
| WO-2001003681-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | PRENDERGAST PATRICK T (IE) | 2001-01-18 | — | — | WO | claimed |
| US-6555523-B1 | Such as 3',4'-diacetoxy-5,6,7-trimethoxyflavone or naringin in the treatment HIV, picornavirus, and/or respiratory virus | CASCADE ESTATES LTD. (MU) | 2003-04-29 | — | — | US | disclosed |
| EP-1223928-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | Prendergast, Patrick Thomas (IE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001003681-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | PRENDERGAST PATRICK T (IE) | 2001-01-18 | — | — | WO | disclosed |