SCHEMBL3135989

SCHEMBL3135989

O=c1cc(-c2cccc(O)c2)oc2cc(O)ccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 1.00
HPGD P15428 5/20 1.00
ALDH1A1 P00352 4/20 1.00
TNKS O95271 3/20 1.00
PARP1 P09874 3/20 1.00
TNKS2 Q9H2K2 3/20 1.00
CYP2C9 P11712 2/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
CYP19A1 P11511 2/20 0.80
MAOA P21397 2/20 0.80
MAOB P27338 2/20 0.80
CA12 O43570 1/20 0.80
AKR1B10 O60218 1/20 0.80
CA1 P00915 1/20 0.80
CA2 P00918 1/20 0.80
CYP1A2 P05177 1/20 0.80
ABCB1 P08183 1/20 0.80
CALM1 P0DP23 1/20 0.80
HSD17B1 P14061 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31675776 1.00 CYP3A4 (1.00) CYP3A4HPGDALDH1A1TNKSPARP1
7-Hydroxyflavone SCHEMBL312148 0.89 CYP19A1 (1.00) CYP3A4HPGDALDH1A1TNKSPARP1
7-Hydroxyflavone SCHEMBL29678183 0.89 CYP19A1 (1.00) CYP3A4HPGDALDH1A1TNKSPARP1
SCHEMBL4277649 0.88 MAPT (1.00) CYP3A4HPGDALDH1A1TNKSPARP1
SCHEMBL29384142 0.88 TNKS (1.00) CYP3A4HPGDALDH1A1TNKSPARP1
7-Hydroxyflavone SCHEMBL10808394 0.88 CYP19A1 (0.97) CYP3A4HPGDALDH1A1TNKSPARP1
7-Hydroxyflavone SCHEMBL27789687 0.88 CYP19A1 (0.97) CYP3A4HPGDALDH1A1TNKSPARP1
SCHEMBL29677954 0.88 TNKS (1.00) CYP3A4HPGDALDH1A1TNKSPARP1
SCHEMBL311580 0.88 TNKS (1.00) CYP3A4HPGDALDH1A1TNKSPARP1
SCHEMBL12829685 0.87 CYP3A4 (0.79) CYP3A4HPGDALDH1A1TNKSPARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122028913-A Oligonucleotides containing ligands in nucleobases, 2 'or 3' positions 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122029177-A Oligonucleotides containing multiple ligands and/or lipids 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122029176-A Containing a plurality of oligonucleotides modified oligonucleotides 阿达尔克斯制药有限公司 2026-05-12 CN claimed
US-20250195452-A1 ER-BETA ESTROGENIC COMPOUNDS AND METHODS OF USE IATERION, INC. 2025-06-19 US claimed
EP-4561582-A1 ER-BETA ESTROGENIC COMPOUNDS AND METHODS OF USE Iaterion, Inc. (US) 2025-06-04 EP claimed
US-20250161459-A1 TRKB LIGAND CONJUGATED COMPOUNDS AND USES THEREOF ADARX PHARMACEUTICALS, INC. (US) 2025-05-22 US claimed
CN-119604294-A ERbeta estrogenic compounds and methods of use 益特瑞恩公司 2025-03-11 CN claimed
WO-2025038960-A1 OLIGONUCLEOTIDES CONTAINING A LIGAND AT AN INTERNAL POSITION ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 WO claimed
WO-2025038963-A1 OLIGONUCLEOTIDES CONTAINING MULTIPLE LIGANDS AND/OR LIPIDS ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 WO claimed
WO-2025038970-A1 MODIFIED OLIGONUCLEOTIDES CONTAINING MULTIPLE OLIGONUCLEOTIDES ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 WO claimed
EP-4475837-A2 TRKB LIGAND CONJUGATED COMPOUNDS AND USES THEREOF Adarx Pharmaceuticals, Inc. (US) 2024-12-18 EP claimed
CN-118973616-A Trkb ligand conjugated compounds and uses thereof 阿达尔克斯制药有限公司 2024-11-15 CN claimed
WO-2024026037-A1 ER-BETA ESTROGENIC COMPOUNDS AND METHODS OF USE IATERION, INC. (US) 2024-02-01 WO claimed
WO-2023154896-A2 TRKB LIGAND CONJUGATED COMPOUNDS AND USES THEREOF ADARX PHARMACEUTICALS, INC. (US) 2023-08-17 WO claimed
US-20130040947-A1 TRKB AGONISTS AND METHODS OF USE EMORY UNIVERSITY (US) 2013-02-14 US claimed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US claimed
JP-2003504327-A 2003-02-04 JP claimed
EP-1223928-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS Prendergast, Patrick Thomas (IE) 2002-07-24 EP claimed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 WO claimed
CN-122028913-A Oligonucleotides containing ligands in nucleobases, 2 'or 3' positions 阿达尔克斯制药有限公司 2026-05-12 CN disclosed
CN-122029177-A Oligonucleotides containing multiple ligands and/or lipids 阿达尔克斯制药有限公司 2026-05-12 CN disclosed
CN-122029176-A Containing a plurality of oligonucleotides modified oligonucleotides 阿达尔克斯制药有限公司 2026-05-12 CN disclosed
US-20250263774-A1 DISCOVERING NEW XENOBIOTIC SUBSTRATES OF AN UDP-GLYCOSYLTRANSFERASE WITH A HIGH-THROUGHPUT METHOD UNIV NORTH TEXAS (US) 2025-08-21 US disclosed
US-20250195452-A1 ER-BETA ESTROGENIC COMPOUNDS AND METHODS OF USE IATERION, INC. 2025-06-19 US disclosed
EP-4561582-A1 ER-BETA ESTROGENIC COMPOUNDS AND METHODS OF USE Iaterion, Inc. (US) 2025-06-04 EP disclosed
US-20250161459-A1 TRKB LIGAND CONJUGATED COMPOUNDS AND USES THEREOF ADARX PHARMACEUTICALS, INC. (US) 2025-05-22 US disclosed
CN-119604294-A ERbeta estrogenic compounds and methods of use 益特瑞恩公司 2025-03-11 CN disclosed
WO-2025038963-A1 OLIGONUCLEOTIDES CONTAINING MULTIPLE LIGANDS AND/OR LIPIDS ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 WO disclosed
WO-2025038960-A1 OLIGONUCLEOTIDES CONTAINING A LIGAND AT AN INTERNAL POSITION ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 WO disclosed
EP-4475837-A2 TRKB LIGAND CONJUGATED COMPOUNDS AND USES THEREOF Adarx Pharmaceuticals, Inc. (US) 2024-12-18 EP disclosed
CN-118973616-A Trkb ligand conjugated compounds and uses thereof 阿达尔克斯制药有限公司 2024-11-15 CN disclosed
EP-3328898-B1 TRKB OR TRKC AGONIST COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC CONDITIONS OTONOMY INC (US) 2024-03-06 EP disclosed
WO-2024026037-A1 ER-BETA ESTROGENIC COMPOUNDS AND METHODS OF USE IATERION, INC. (US) 2024-02-01 WO disclosed
WO-2023154896-A2 TRKB LIGAND CONJUGATED COMPOUNDS AND USES THEREOF ADARX PHARMACEUTICALS, INC. (US) 2023-08-17 WO disclosed
WO-2023154896-A2 TRKB LIGAND CONJUGATED COMPOUNDS AND USES THEREOF ADARX PHARMACEUTICALS, INC. (US) 2023-08-17 WO disclosed
US-11185527-B2 Methods and compositions relating to steroid hormone receptor-dependent cancers WAYNE STATE UNIVERSITY (US) 2021-11-30 US disclosed
US-11013717-B1 Methods and compositions for treating cancer using SERCA pump inhibitors FLAGSHIP PIONEERING INNOVATIONS V, INC. (US) 2021-05-25 US disclosed
US-20200397907-A1 TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF OTONOMY, INC. 2020-12-24 US disclosed
US-10821185-B2 Triglyceride otic formulations and uses thereof OTONOMY INC. (US) 2020-11-03 US disclosed
US-20200190201-A1 TRKB OR TRKC AGONIST COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC CONDITIONS OTONOMY, INC. 2020-06-18 US disclosed
US-20200155501-A1 METHODS AND COMPOSITIONS RELATING TO STEROID HORMONE RECEPTOR-DEPENDENT CANCERS WAYNE STATE UNIVERSITY (US) 2020-05-21 US disclosed
US-10398760-B2 Method of treating pain using agents that promote neuronal differentiation RUSANESCU GABRIEL (US) 2019-09-03 US disclosed
EP-3506926-A1 NEUROMODULATING COMPOSITIONS AND RELATED THERAPEUTIC METHODS FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES Flagship Pioneering Innovations V, Inc. (US) 2019-07-10 EP disclosed
EP-3478269-A1 TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF Otonomy, Inc. (US) 2019-05-08 EP disclosed
CN-109689027-A Triglycerides aural preparations and application thereof 奥德纳米有限公司 2019-04-26 CN disclosed
CN-108699160-A TrkB or TrkC agonist compositions and methods for treating otic conditions 奥德纳米有限公司 2018-10-23 CN disclosed
EP-3328898-A1 TRKB OR TRKC AGONIST COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC CONDITIONS Otonomy, Inc. (US) 2018-06-06 EP disclosed
EP-2579870-B1 TRKB AGONISTS AND METHODS OF USE UNIV EMORY (US) 2018-02-14 EP disclosed
WO-2018022664-A1 NEUROMODULATING COMPOSITIONS AND RELATED THERAPEUTIC METHODS FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES FLAGSHIP PIONEERING, INC. (US) 2018-02-01 WO disclosed
US-20180000950-A1 TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF OTONOMY, INC. 2018-01-04 US disclosed
US-20180000897-A1 Method of treating pain using agents that promote neuronal differentiation RUSANESCU GABRIEL (US) 2018-01-04 US disclosed
WO-2018005830-A1 TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF OTONOMY, INC. (US) 2018-01-04 WO disclosed
EP-2730431-B1 Rubber composition and tire with rubber containing flavone GOODYEAR TIRE & RUBBER (US) 2017-06-28 EP disclosed
US-20170029511-A1 TRKB OR TRKC AGONIST COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC CONDITIONS OTONOMY, INC. 2017-02-02 US disclosed
WO-2017019907-A1 TRKB OR TRKC AGONIST COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC CONDITIONS OTONOMY, INC. (US) 2017-02-02 WO disclosed
US-9504674-B2 TrkB agonists and methods of use EMORY UNIVERSITY (US) 2016-11-29 US disclosed
US-9504674-B2 TrkB agonists and methods of use EMORY UNIVERSITY (US) 2016-11-29 US disclosed
US-20150174107-A1 TRKB AGONISTS AND METHODS OF USE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-06-25 US disclosed
US-20150174107-A1 TRKB AGONISTS AND METHODS OF USE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-06-25 US disclosed
US-9029561-B2 TRKB agonists and methods of use EMORY UNIVERSITY (US) 2015-05-12 US disclosed
US-9029561-B2 TRKB agonists and methods of use EMORY UNIVERSITY (US) 2015-05-12 US disclosed
US-20140135433-A1 TIRE WITH RUBBER CONTAINING FLAVONE THE GOODYEAR TIRE & RUBBER COMPANY (US) 2014-05-15 US disclosed
EP-2730431-A1 Rubber composition and tire with rubber containing flavone The Goodyear Tire & Rubber Company (US) 2014-05-14 EP disclosed
EP-2579870-A2 TRKB AGONISTS AND METHODS OF USE Emory University (US) 2013-04-17 EP disclosed
US-20130040947-A1 TRKB AGONISTS AND METHODS OF USE EMORY UNIVERSITY (US) 2013-02-14 US disclosed
US-20130040947-A1 TRKB AGONISTS AND METHODS OF USE EMORY UNIVERSITY (US) 2013-02-14 US disclosed
WO-2011156479-A9 TRKB AGONISTS AND METHODS OF USE EMORY UNIVERSITY (US) 2012-05-31 WO disclosed
WO-2011156479-A2 TRKB AGONISTS AND METHODS OF USE EMORY UNIVERSITY (US) 2011-12-15 WO disclosed
US-20100092578-A1 PROTEIN KINASE C IOTA NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-04-15 US disclosed
US-7642400-B2 Transgenic animals, inhibitors of PKC iota signaling, methods for inhibiting PKC iota signaling, identifying inhibitors of PKC iota signaling, and methods for diagnosing cancer MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2010-01-05 US disclosed
WO-2009026657-A1 FLAVONOID PPAR AGONISTS THE UNIVERSITY OF SYDNEY (AU) 2009-03-05 WO disclosed
WO-2007115181-A9 COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF EASTMAN CHEM CO (US) 2008-04-03 WO disclosed
US-20070283451-A1 Protein Kinase C Iota NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2007-12-06 US disclosed
US-20070254859-A1 Compounds exhibiting efflux inhibitor activity and composition and uses thereof EASTMAN CHEMICAL COMPANY 2007-11-01 US disclosed
WO-2007115181-A2 COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF EASTMAN CHEMICAL COMPANY (US) 2007-10-11 WO disclosed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US disclosed
WO-2003057210-A1 COMPOSITIONS AND METHODS FOR INCREASING CELL PROLIFERATION COMPRISING A FLAVONOID KIMBERLY-CLARK WORLDWIDE, INC. (US) 2003-07-17 WO disclosed
US-20030125264-A1 Methods For Treating Wounds KIMBERLY-CLARK WORLDWIDE, INC. 2003-07-03 US disclosed
US-6555523-B1 Such as 3',4'-diacetoxy-5,6,7-trimethoxyflavone or naringin in the treatment HIV, picornavirus, and/or respiratory virus CASCADE ESTATES LTD. (MU) 2003-04-29 US disclosed
EP-1223928-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS Prendergast, Patrick Thomas (IE) 2002-07-24 EP disclosed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 WO disclosed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11185527-B2 Methods and compositions relating to steroid hormone receptor-dependent cancers ESRRA, ESRRB, NR3C1 CYP3A4 4111/4885HPGD 2535/4885ALDH1A1 3338/4885
US-20070254859-A1 Compounds exhibiting efflux inhibitor activity and composition and uses thereof ABCC4, NCOA4, NR4A3 CYP3A4 17/4885HPGD 1949/4885ALDH1A1 2000/4885
US-20180000950-A1 TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF CETP, LIPA, APOB CYP3A4 4231/4885HPGD 1152/4885ALDH1A1 1277/4885
US-20130040947-A1 TRKB AGONISTS AND METHODS OF USE NTRK2, BDNF, NTRK1 CYP3A4 1228/4885HPGD 1465/4885ALDH1A1 1116/4885
US-20250195452-A1 ER-BETA ESTROGENIC COMPOUNDS AND METHODS OF USE ESR2, ESR1, ESRRB CYP3A4 210/4885HPGD 922/4885ALDH1A1 3391/4885
US-20150174107-A1 TRKB AGONISTS AND METHODS OF USE NTRK2, BDNF, NTRK1 CYP3A4 1323/4885HPGD 1862/4885ALDH1A1 1274/4885
US-20200190201-A1 TRKB OR TRKC AGONIST COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC CONDITIONS NTRK2, NTRK1, NTRK3 CYP3A4 4825/4885HPGD 3543/4885ALDH1A1 2996/4885
US-20250161459-A1 TRKB LIGAND CONJUGATED COMPOUNDS AND USES THEREOF NTRK2, NTRK1, BDNF CYP3A4 4808/4885HPGD 3368/4885ALDH1A1 1653/4885
US-10821185-B2 Triglyceride otic formulations and uses thereof CETP, LIPA, APOB CYP3A4 4231/4885HPGD 1152/4885ALDH1A1 1277/4885
US-20170029511-A1 TRKB OR TRKC AGONIST COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC CONDITIONS NTRK2, NTRK1, NTRK3 CYP3A4 4825/4885HPGD 3543/4885ALDH1A1 2996/4885
US-20030125264-A1 Methods For Treating Wounds FGF2, MMP1, FIBP CYP3A4 3010/4885HPGD 558/4885ALDH1A1 2440/4885
US-20200397907-A1 TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF CETP, LIPA, APOB CYP3A4 4231/4885HPGD 1152/4885ALDH1A1 1277/4885
US-20200155501-A1 METHODS AND COMPOSITIONS RELATING TO STEROID HORMONE RECEPTOR-DEPENDENT CANCERS ESRRA, ESRRB, NR3C1 CYP3A4 4448/4885HPGD 2740/4885ALDH1A1 3533/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.