Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 8/20 | 0.82 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.49 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 3/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.44 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12129515 | 0.90 | CXCL8 (1.00) | CXCL8PTGS2PTGS1ABCB11NR1I3 | |
| SCHEMBL3151521 | 0.90 | CXCL8 (1.00) | CXCL8PTGS2PTGS1ABCB11NR1I3 | |
| SCHEMBL3137707 | 0.90 | CXCL8 (1.00) | CXCL8PTGS2PTGS1ABCB11NR1I3 | |
| SCHEMBL5975932 | 0.84 | CXCL8 (0.57) | CXCL8PTGS2PTGS1ABCB11NR1I3 | |
| SCHEMBL1679090 | 0.77 | CXCL8 (0.56) | CXCL8PTGS2PTGS1LMNAKMT2A | |
| SCHEMBL10992714 | 0.76 | CXCL8 (0.73) | CXCL8PTGS2PTGS1ABCB11NR1I3 | |
| SCHEMBL27595572 | 0.76 | PTGS2 (0.64) | CXCL8PTGS2PTGS1ABCB11NR1I3 | |
| SCHEMBL7716835 | 0.76 | CXCL8 (0.73) | CXCL8PTGS2PTGS1ABCB11NR1I3 | |
| SCHEMBL11403823 | 0.76 | CXCL8 (0.73) | CXCL8PTGS2PTGS1ABCB11NR1I3 | |
| SCHEMBL28809681 | 0.75 | CXCL8 (0.71) | CXCL8PTGS2PTGS1ABCB11NR1I3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100490797-C | Pharmaceutical composition | NOVARTIS AG (CH) | 2009-05-27 | — | — | CN | claimed |
| CN-100406008-C | Pharmaceutical composition comprising lumiracoxib | NOVARTIS AG (CH) | 2008-07-30 | — | — | CN | claimed |
| CN-1455691-A | Pharmaceutical composition | NOVARTIS AG (CH) | 2003-11-12 | — | — | CN | claimed |
| CN-1330300-C | Pharmaceutical compositions | NOVARTIS AG (CH) | 2007-08-08 | — | — | CN | disclosed |
| CN-1638752-A | Pharmaceutical compositions | NOVARTIS AG (CH) | 2005-07-13 | — | — | CN | disclosed |
| US-20030114527-A1 | Pharmaceutical composition | NOVARTIS AG (CH) | 2003-06-19 | — | — | US | disclosed |