Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.31 |
| ▸ | GPR3 | P46089 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7129091 | 0.81 | GPR3 (0.34) | GPR3CYP19A1 | |
| Hydrochloric Acid SCHEMBL3124496 | 0.80 | POLB (0.42) | GPR3POLBCYP19A1SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL7116300 | 0.71 | NTRK1 (0.37) | GPR3POLB | |
| Hydrochloric Acid SCHEMBL7119556 | 0.71 | GPR3 (0.36) | GPR3CYP19A1SLC6A4SLC6A3 | |
| SCHEMBL7116318 | 0.69 | HTR2A (0.42) | GPR3CYP19A1SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL29479996 | 0.68 | POLB (0.36) | GPR3POLB | |
| Hydrochloric Acid SCHEMBL5003676 | 0.68 | SLC6A2 (0.42) | GPR3POLBSLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL7127308 | 0.67 | KDM4E (0.39) | POLB | |
| Hydrochloric Acid SCHEMBL7129119 | 0.66 | WDR5 (0.38) | GPR3 | |
| Hydrochloric Acid SCHEMBL6911930 | 0.65 | POLB (0.31) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030148877-A1 | Metallocenes and catalysts for olefin-polymerisation | BASELL TECHNOLOGY COMPANY BV (NL) | 2003-08-07 | — | — | US | disclosed |
| EP-0952978-B1 | METALLOCENES AND CATALYSTS FOR OLEFIN-POLYMERISATION | BASELL POLYOLEFINE GMBH (DE) | 2003-01-22 | — | — | EP | disclosed |
| US-6451724-B1 | BIS(N-METHYL-5,10-DIHYDROINDENO(1,2-B)INDOL-10 -YL)TITANIUM DICHLORIDE | BASELL TECHNOLOGY COMPANY BV (NL) | 2002-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030148877-A1 | Metallocenes and catalysts for olefin-polymerisation | MT-CO1, CPNE4, MT-CO3 | SLC6A3 4225/4885GPR3 3696/4885POLB 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.