Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6138837 | 0.86 | BRD4 (0.31) | PDCD1CD274 | |
| Hydrochloric Acid SCHEMBL5507009 | 0.85 | PDCD1 (0.32) | PDCD1CD274ALDH1A1HSD17B10CHRNB2 | |
| Hydrochloric Acid SCHEMBL27537901 | 0.78 | PDCD1 (0.35) | PDCD1CD274ALDH1A1HSD17B10CHRNB2 | |
| SCHEMBL6911211 | 0.76 | PDCD1 (0.36) | PDCD1CD274ALDH1A1HSD17B10CHRNB2 | |
| Hydrochloric Acid SCHEMBL5709139 | 0.75 | PDCD1 (0.35) | PDCD1CD274ALDH1A1HSD17B10CHRNB2 | |
| Hydrochloric Acid SCHEMBL4079019 | 0.75 | PDCD1 (0.35) | PDCD1CD274ALDH1A1HSD17B10CHRNB2 | |
| Hydrochloric Acid SCHEMBL5709184 | 0.75 | PDCD1 (0.35) | PDCD1CD274ALDH1A1HSD17B10CHRNB2 | |
| Hydrochloric Acid SCHEMBL27384615 | 0.75 | PDCD1 (0.35) | PDCD1CD274ALDH1A1HSD17B10CHRNB2 | |
| Hydrochloric Acid SCHEMBL29424591 | 0.75 | PDCD1 (0.35) | PDCD1CD274ALDH1A1HSD17B10CHRNB2 | |
| Hydrochloric Acid SCHEMBL3163965 | 0.75 | PDCD1 (0.35) | PDCD1CD274ALDH1A1HSD17B10CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6664352-B1 | Impregnating porous particulate support in mechanically fluidized state with catalyst material in mixer having horizontal axis counter-rotating interlocking mixing paddles | BOREALIS TECHNOLOGY OY (FI) | 2003-12-16 | — | — | US | disclosed |