SCHEMBL712860

SCHEMBL712860

O=C1c2ccccc2C(=O)N1CCCCCCI

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.64
L3MBTL1 Q9Y468 1/20 0.64
CHRM2 P08172 2/20 0.57
MEN1 O00255 1/20 0.57
CYP1A2 P05177 1/20 0.57
CYP2C19 P33261 1/20 0.57
KMT2A Q03164 1/20 0.57
HDAC8 Q9BY41 3/20 0.57
HDAC3 O15379 2/20 0.57
HDAC4 P56524 2/20 0.57
HDAC1 Q13547 2/20 0.57
HDAC7 Q8WUI4 2/20 0.57
HDAC2 Q92769 2/20 0.57
HDAC10 Q969S8 2/20 0.57
HDAC11 Q96DB2 2/20 0.57
HDAC6 Q9UBN7 2/20 0.57
HDAC9 Q9UKV0 2/20 0.57
HDAC5 Q9UQL6 2/20 0.57
ACHE P22303 4/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7259722 1.00 TDP1 (0.64) TDP1L3MBTL1CHRM2MEN1CYP1A2
SCHEMBL24468061 1.00 TDP1 (0.64) TDP1L3MBTL1CHRM2MEN1CYP1A2
SCHEMBL6575878 0.98 TDP1 (0.61) TDP1L3MBTL1CHRM2MEN1CYP1A2
SCHEMBL766369 0.94 TDP1 (0.59) TDP1L3MBTL1CHRM2MEN1CYP1A2
SCHEMBL8862878 0.90 TDP1 (0.75) TDP1L3MBTL1CHRM2MEN1CYP1A2
SCHEMBL2604742 0.90 TDP1 (0.75) TDP1L3MBTL1CHRM2MEN1CYP1A2
SCHEMBL6777483 0.90 TDP1 (0.75) TDP1L3MBTL1CHRM2MEN1CYP1A2
SCHEMBL8862728 0.90 TDP1 (0.75) TDP1L3MBTL1CHRM2MEN1CYP1A2
SCHEMBL8863154 0.90 TDP1 (0.75) TDP1L3MBTL1CHRM2MEN1CYP1A2
SCHEMBL8863094 0.90 TDP1 (0.75) TDP1L3MBTL1CHRM2MEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4700124-A2 OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION Alnylam Pharmaceuticals, Inc. (US) 2026-02-25 EP disclosed
US-12398121-B2 Anti-cancer nuclear hormone receptor-targeting compounds NUVATION BIO INC. (US) 2025-08-26 US disclosed
US-20250075208-A1 OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION BANK OF AMERICA, N.A. 2025-03-06 US disclosed
US-12173288-B2 Oligonucleotide-ligand conjugates and process for their preparation ALNYLAM PHARMACEUTICALS, INC. (US) 2024-12-24 US disclosed
WO-2023113456-A1 NOVEL COMPOUND FOR DEGRADING TARGET PROTEIN OR POLYPEPTIDE BY USING POLYUBIQUITINATION (주)프레이저테라퓨틱스 2023-06-22 WO disclosed
WO-2023113456-A1 NOVEL COMPOUND FOR DEGRADING TARGET PROTEIN OR POLYPEPTIDE BY USING POLYUBIQUITINATION (주)프레이저테라퓨틱스 2023-06-22 WO disclosed
US-20230122310-A1 ANTI-CANCER NUCLEAR HORMONE RECEPTOR-TARGETING COMPOUNDS SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) 2023-04-20 US disclosed
US-20230122310-A1 ANTI-CANCER NUCLEAR HORMONE RECEPTOR-TARGETING COMPOUNDS SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) 2023-04-20 US disclosed
US-20220348914-A1 OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION BANK OF AMERICA, N.A. 2022-11-03 US disclosed
EP-4039278-A1 OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION Alnylam Pharmaceuticals, Inc. (US) 2022-08-10 EP disclosed
US-20120053336-A1 Nucleic Acid Labelling Compounds AFFYMETRIX, INC. (US) 2012-03-01 US disclosed
US-8076072-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2011-12-13 US disclosed
US-8026057-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2011-09-27 US disclosed
US-20110082289-A1 Nucleic Acid Labeling Compounds AFFYMETRIC, INC. (US) 2011-04-07 US disclosed
US-7468243-B2 Nucleotide sequence labelling compoumd four use as tool in genetic engineering AFFYMETRIX, INC. (US) 2008-12-23 US disclosed
US-20080287667-A1 Nucleic Acid Labeling Compounds AFFYMETRIX, INC. (US) 2008-11-20 US disclosed
EP-1385829-A4 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX INC (US) 2005-10-19 EP disclosed
EP-1385829-A2 NUCLEIC ACID LABELING COMPOUNDS Affymetrix, Inc. (US) 2004-02-04 EP disclosed
US-20020182625-A1 Nucleotide sequence labelling compoumd four use as tool in genetic engineering AFFYMETRIX, INC. 2002-12-05 US disclosed
WO-2002072779-A2 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX, INC. (US) 2002-09-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12398121-B2 Anti-cancer nuclear hormone receptor-targeting compounds NCOA1, NCOR1, NCOA3 TDP1 3764/4885L3MBTL1 3229/4885CHRM2 4655/4885
US-20110082289-A1 Nucleic Acid Labeling Compounds RNGTT, DUT, FBL TDP1 207/4885L3MBTL1 1158/4885CHRM2 4885/4885
US-20080287667-A1 Nucleic Acid Labeling Compounds RNGTT, DUT, FBL TDP1 275/4885L3MBTL1 1152/4885CHRM2 4885/4885
US-20220348914-A1 OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION IGF2R, IRS1, INSR TDP1 1363/4885L3MBTL1 1657/4885CHRM2 3553/4885
US-12173288-B2 Oligonucleotide-ligand conjugates and process for their preparation IGF2R, IRS1, INSR TDP1 1363/4885L3MBTL1 1657/4885CHRM2 3553/4885
US-20120053336-A1 Nucleic Acid Labelling Compounds RNGTT, DUT, FBL TDP1 215/4885L3MBTL1 1039/4885CHRM2 4885/4885
US-20230122310-A1 ANTI-CANCER NUCLEAR HORMONE RECEPTOR-TARGETING COMPOUNDS NCOA1, NCOR1, NCOA3 TDP1 3764/4885L3MBTL1 3229/4885CHRM2 4655/4885
US-20250075208-A1 OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION IGF2R, IRS1, INSR TDP1 1363/4885L3MBTL1 1657/4885CHRM2 3553/4885
US-20020182625-A1 Nucleotide sequence labelling compoumd four use as tool in genetic engineering RNGTT, POLM, RNMT TDP1 239/4885L3MBTL1 470/4885CHRM2 4855/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.