Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 14/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | PTPRB | P23467 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7121163 | 0.82 | CETP (0.36) | CETPPTGDR2PTGDRDHODHPTPRB | |
| SCHEMBL6421617 | 0.82 | CETP (0.42) | CETPPTGDR2PTGDR | |
| SCHEMBL6380661 | 0.73 | GCGR (0.38) | CETPDHODH | |
| SCHEMBL7123071 | 0.71 | ALPL (0.36) | PTGDR2PTGDR | |
| SCHEMBL27493415 | 0.71 | CETP (0.63) | CETP | |
| SCHEMBL6476093 | 0.71 | CETP (0.59) | CETP | |
| SCHEMBL4499541 | 0.69 | CETP (0.46) | CETP | |
| SCHEMBL6422216 | 0.66 | CETP (0.37) | CETPPTGDR2PTGDRPTPRB | |
| SCHEMBL6424280 | 0.66 | CETP (0.35) | CETPPTGDR2PTGDR | |
| SCHEMBL6422071 | 0.65 | ALPL (0.35) | CETPPTGDR2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586613-B1 | Compounds such as 5-(tert-butyldimethylsiloxy)-7,7-dimethyl -4(4-fluorophenyl)-3-(hydroxy-(4-trifluorophenyl)-methyl)-2-isopropyl -5,6,7,8-tetrahydronaphthalene, used as antagonists for cholesteryl ester transferase protein; hyperlipemia | BAYER AKTIENGELLSCHAFT (DE) | 2003-07-01 | — | — | US | disclosed |