Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EBP | Q15125 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.34 |
| ▸ | PTGFR | P43088 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 4/20 | 0.32 |
| ▸ | ACE | P12821 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7123235 | 0.86 | L3MBTL1 (0.43) | L3MBTL1EBPSIGMAR1FFAR1POLB | |
| SCHEMBL7131088 | 0.84 | L3MBTL1 (0.43) | L3MBTL1EBPSIGMAR1FFAR1SMN1; SMN2 | |
| SCHEMBL7120022 | 0.84 | L3MBTL1 (0.43) | L3MBTL1EBPSIGMAR1FFAR1ALDH1A1 | |
| SCHEMBL7129611 | 0.84 | L3MBTL1 (0.43) | L3MBTL1EBPSIGMAR1KIF11FFAR1 | |
| SCHEMBL5751980 | 0.81 | EBP (0.51) | L3MBTL1EBPSIGMAR1KCNH2KIF11 | |
| SCHEMBL10631498 | 0.80 | L3MBTL1 (0.44) | L3MBTL1EBPSIGMAR1HTR2AHTR2C | |
| SCHEMBL21632134 | 0.79 | HTR2A (0.38) | HTR2AHTR2CADRA1AOPRK1KCNH2 | |
| SCHEMBL11097563 | 0.79 | FFAR1 (0.38) | HTR2AHTR2CADRA1AOPRK1KCNH2 | |
| SCHEMBL7128373 | 0.78 | MIF (0.41) | L3MBTL1EBPSIGMAR1FFAR1NPC1 | |
| SCHEMBL7121340 | 0.77 | CYP3A4 (0.39) | EBPSIGMAR1HTR2AHTR2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6667412-B1 | Carboxylic acid, ester or alcohol derivatives; n,n-substi-tuted cyclic amine or phenylacetonitrile intermediates; low cost; stability, workability, final product purity | EISAI CO., LTD. (JP) | 2003-12-23 | — | — | US | claimed |
| EP-1167348-A1 | NITRILE DERIVATIVES | Eisai Co., Ltd. (JP) | 2002-01-02 | — | — | EP | claimed |
| US-6667412-B1 | Carboxylic acid, ester or alcohol derivatives; n,n-substi-tuted cyclic amine or phenylacetonitrile intermediates; low cost; stability, workability, final product purity | EISAI CO., LTD. (JP) | 2003-12-23 | — | — | US | disclosed |
| EP-1167348-A1 | NITRILE DERIVATIVES | Eisai Co., Ltd. (JP) | 2002-01-02 | — | — | EP | disclosed |