Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 5/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | GPX4 | P36969 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029679 | 0.88 | GPX4 (0.35) | OPRM1SLC6A9DRD2TBXA2RGPX4 | |
| SCHEMBL3297618 | 0.85 | GPX4 (0.34) | SLC6A9GPX4 | |
| SCHEMBL3299155 | 0.83 | GPX4 (0.34) | SLC6A9GPX4KCNH2ALDH1A1 | |
| SCHEMBL3298446 | 0.83 | GPX4 (0.34) | SLC6A9GPX4KCNH2ALDH1A1 | |
| SCHEMBL7650011 | 0.83 | FFAR2 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7653080 | 0.83 | FFAR2 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3295171 | 0.82 | HSD17B10 (0.34) | SLC6A9GPX4 | |
| SCHEMBL6645535 | 0.81 | OPRD1 (0.42) | OPRD1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7646797 | 0.81 | CNR1 (0.39) | — | |
| SCHEMBL7652230 | 0.78 | MEN1 (0.40) | FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112251-B1 | AZETIDINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-05-07 | — | — | EP | disclosed |