Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GBA1 | P04062 | 1/20 | 0.56 |
| ▸ | IGF2R | P11717 | 2/20 | 0.41 |
| ▸ | P2RY2 | P41231 | 8/20 | 0.41 |
| ▸ | IDUA | P35475 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | MANBA | O00462 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13997127 | 1.00 | LMNA (0.56) | LMNAGBA1IGF2RP2RY2IDUA | |
| SCHEMBL5058318 | 0.83 | LMNA (0.53) | LMNAGBA1IDUAGUSBHIF1A | |
| SCHEMBL20402676 | 0.77 | LMNA (0.70) | LMNAGBA1IDUAGUSBHIF1A | |
| SCHEMBL2028658 | 0.74 | FBP1 (0.59) | LMNAGBA1IGF2R | |
| Gluconolactone SCHEMBL11053856 | 0.74 | LMNA (0.76) | LMNAGBA1IDUAGUSBHIF1A | |
| SCHEMBL25778394 | 0.74 | FBP1 (0.59) | LMNAGBA1IGF2R | |
| SCHEMBL15670703 | 0.74 | FBP1 (0.59) | LMNAGBA1IGF2R | |
| SCHEMBL50310 | 0.74 | FBP1 (0.59) | LMNAGBA1IGF2R | |
| SCHEMBL16325387 | 0.73 | LMNA (0.58) | LMNAGBA1IDUAGUSBHIF1A | |
| Gluconolactone SCHEMBL24637666 | 0.72 | LMNA (1.00) | LMNAGBA1IDUAGUSBHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670399-B2 | Contacting a blood vessel wall cell with an A beta 40 inhibitor, such that cerebral amyloid angiopathy is inhibited | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2003-12-30 | — | — | US | disclosed |