Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3045995 | 0.78 | ALDH1A1 (0.59) | POLBPARP1ALDH1A1KCNK3KCNK9 | |
| SCHEMBL1794480 | 0.76 | PARP1 (0.56) | POLBPARP1ALDH1A1KCNK3KCNK9 | |
| SCHEMBL13059672 | 0.76 | CES2 (0.55) | PARP1ALDH1A1KCNK3KCNK9HPGD | |
| SCHEMBL16891401 | 0.76 | POLB (0.53) | POLBPARP1ALDH1A1KCNK3KCNK9 | |
| Water SCHEMBL8938090 | 0.76 | ALDH1A1 (0.57) | POLBPARP1ALDH1A1KCNK3KCNK9 | |
| SCHEMBL7094841 | 0.74 | CES2 (0.48) | ALDH1A1MAPTHPGDLMNAMAOB | |
| SCHEMBL674193 | 0.74 | PARP1 (0.54) | POLBPARP1ALDH1A1KCNK3KCNK9 | |
| SCHEMBL27320796 | 0.74 | PARP1 (0.59) | POLBPARP1ALDH1A1KCNK3KCNK9 | |
| SCHEMBL58595 | 0.73 | ALDH1A1 (0.54) | POLBPARP1ALDH1A1MAPTHPGD | |
| SCHEMBL22734773 | 0.73 | PARP1 (0.53) | POLBPARP1ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047515-A2 | P2X7 RECEPTOR ANTAGONISTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2003-06-12 | — | — | WO | claimed |
| WO-2003047515-A2 | P2X7 RECEPTOR ANTAGONISTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2003-06-12 | — | — | WO | disclosed |