Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.60 |
| ▸ | TMEM97 | Q5BJF2 | 9/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 3/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.52 |
| ▸ | NAAA | Q02083 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7169601 | 0.89 | SIGMAR1 (0.57) | SIGMAR1TMEM97NPC1RAB9AAPP | |
| SCHEMBL10621481 | 0.81 | TMEM97 (0.59) | SIGMAR1TMEM97NPC1RAB9AACKR3 | |
| SCHEMBL13579952 | 0.81 | SIGMAR1 (0.83) | SIGMAR1TMEM97APPACKR3 | |
| SCHEMBL7129202 | 0.79 | NPC1 (0.53) | SIGMAR1TMEM97NPC1RAB9AAPP | |
| SCHEMBL27389180 | 0.79 | HDAC1 (0.67) | NPC1RAB9AHDAC1HDAC2HDAC8 | |
| SCHEMBL30576437 | 0.79 | APP (0.59) | SIGMAR1TMEM97APPHDAC1HDAC2 | |
| SCHEMBL4768363 | 0.77 | NPC1 (0.66) | NPC1RAB9AHDAC1HDAC2HDAC8 | |
| SCHEMBL8779817 | 0.77 | HDAC1 (0.79) | NPC1RAB9AHDAC1HDAC2HDAC8 | |
| SCHEMBL7125002 | 0.77 | APP (0.49) | SIGMAR1TMEM97APPDRD2DRD4 | |
| SCHEMBL17372684 | 0.76 | SIGMAR1 (0.82) | SIGMAR1TMEM97APPACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670400-B1 | Secretion inhibitors for gastric acid, antiemetics; N(4-(2-(2-methoxyphenoxy)ethyl)aminobutyl)benzamide; | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2003-12-30 | — | — | US | disclosed |
| EP-0929525-B1 | HETEROARYLOXYETHYLAMINES AS 5-HT1A RECEPTOR LIGANDS | SOD CONSEILS RECH APPLIC (FR) | 2002-09-04 | — | — | EP | disclosed |
| EP-0820434-B1 | PHENOXYETHYLAMINE DERIVATIVES HAVING HIGH AFFINITY FOR THE 5-HT 1A RECEPTOR, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SOD CONSEILS RECH APPLIC (FR) | 2000-08-09 | — | — | EP | disclosed |
| US-6063784-A | HYPOTENSIVE AGENTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S. ) (FR) | 2000-05-16 | — | — | US | disclosed |
| CN-1183765-A | Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, process for their preparation, their use as medicaments and pharmaceutical compositions containing them | SOD CONSEILS RECH APPLIC (FR) | 1998-06-03 | — | — | CN | disclosed |
| EP-0820434-A1 | PHENOXYETHYLAMINE DERIVATIVES HAVING HIGH AFFINITY FOR THE 5-HT 1A RECEPTOR, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996031461-A1 | PHENOXYETHYLAMINE DERIVATIVES HAVING HIGH AFFINITY FOR THE 5-HT1A RECEPTOR, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1996-10-10 | — | — | WO | disclosed |