Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7125002 | 0.87 | APP (0.49) | SIGMAR1TMEM97APPACKR3DRD2 | |
| SCHEMBL7126384 | 0.86 | SIGMAR1 (0.47) | NPC1SIGMAR1TMEM97APPRAB9A | |
| SCHEMBL8063854 | 0.84 | KDM4E (0.51) | NPC1SIGMAR1TMEM97APPRAB9A | |
| SCHEMBL8150113 | 0.82 | HCRTR2 (0.49) | SMN1; SMN2HCRTR2 | |
| SCHEMBL7573340 | 0.82 | POLB (0.50) | NPC1SIGMAR1TMEM97RAB9ASMN1; SMN2 | |
| SCHEMBL7764563 | 0.82 | LMNA (0.58) | SMN1; SMN2HCRTR2 | |
| SCHEMBL7122678 | 0.81 | HTR1D (0.51) | SMN1; SMN2HCRTR2 | |
| SCHEMBL7129424 | 0.79 | NPC1 (0.65) | NPC1HSP90AA1RAB9ADRD2DRD4 | |
| SCHEMBL7129442 | 0.79 | SIGMAR1 (0.60) | NPC1SIGMAR1TMEM97APPRAB9A | |
| SCHEMBL7169601 | 0.79 | SIGMAR1 (0.57) | NPC1SIGMAR1TMEM97APPRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670400-B1 | Secretion inhibitors for gastric acid, antiemetics; N(4-(2-(2-methoxyphenoxy)ethyl)aminobutyl)benzamide; | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2003-12-30 | — | — | US | disclosed |
| EP-0820434-B1 | PHENOXYETHYLAMINE DERIVATIVES HAVING HIGH AFFINITY FOR THE 5-HT 1A RECEPTOR, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SOD CONSEILS RECH APPLIC (FR) | 2000-08-09 | — | — | EP | disclosed |
| EP-0820434-A1 | PHENOXYETHYLAMINE DERIVATIVES HAVING HIGH AFFINITY FOR THE 5-HT 1A RECEPTOR, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996031461-A1 | PHENOXYETHYLAMINE DERIVATIVES HAVING HIGH AFFINITY FOR THE 5-HT1A RECEPTOR, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1996-10-10 | — | — | WO | disclosed |