Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.40 |
| ▸ | TNKS | O95271 | 2/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204870 | 0.88 | MEN1 (0.43) | TDP1ALDH1A1L3MBTL1MAPTGUSB | |
| SCHEMBL7129510 | 0.81 | PKN1 (0.53) | TDP1ALDH1A1L3MBTL1AMY1ATNKS | |
| SCHEMBL5202015 | 0.80 | RPS6KA2 (0.45) | AMY1ARPS6KA2MAPTGUSBNPC1 | |
| SCHEMBL9044504 | 0.77 | GUSB (0.56) | TDP1ALDH1A1L3MBTL1AMY1AMAPT | |
| SCHEMBL2361351 | 0.73 | AMY1A (0.45) | ALDH1A1AMY1AMAPT | |
| SCHEMBL1895139 | 0.72 | MEN1 (0.56) | TDP1ALDH1A1L3MBTL1TNKSTNKS2 | |
| SCHEMBL5771322 | 0.71 | PARP1 (0.48) | TDP1ALDH1A1L3MBTL1TNKSTNKS2 | |
| SCHEMBL1013587 | 0.71 | MAPT (0.53) | TDP1ALDH1A1L3MBTL1MAPTKDM4E | |
| SCHEMBL7159716 | 0.70 | ALDH1A1 (0.71) | TDP1ALDH1A1L3MBTL1MAPTKDM4E | |
| SCHEMBL13405986 | 0.70 | NQO2 (0.46) | ALDH1A1AMY1AMAPTGUSBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0963371-B1 | SUBSTITUTED BENZIMIDAZOLES AS NON-NUCLEOSIDE INHIBITORS OF REVERSE TRANSCRIPTASE | US GOV HEALTH & HUMAN SERV (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-0963371-A1 | SUBSTITUTED BENZIMIDAZOLES AS NON-NUCLEOSIDE INHIBITORS OF REVERSE TRANSCRIPTASE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1999-12-15 | — | — | EP | disclosed |
| WO-1998037072-A1 | SUBSTITUTED BENZIMIDAZOLES AS NON-NUCLEOSIDE INHIBITORS OF REVERSE TRANSCRIPTASE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-08-27 | — | — | WO | disclosed |