Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.31 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8472714 | 0.82 | KMT2A (0.38) | HPGDPTGER4PTGER3PTGER2TDP1 | |
| SCHEMBL6152520 | 0.75 | HPGD (0.39) | HPGDPTGER4PTGER3PTGER2TDP1 | |
| SCHEMBL11941054 | 0.73 | CTSB (0.41) | HPGDTDP1MEN1HTTKMT2A | |
| SCHEMBL9501496 | 0.72 | GPR52 (0.40) | PTGER4PTGER3PTGER2MEN1KMT2A | |
| SCHEMBL9501489 | 0.72 | GPR52 (0.40) | PTGER4PTGER3PTGER2MEN1KMT2A | |
| SCHEMBL14465955 | 0.72 | CYSLTR2 (0.36) | KMT2ACYSLTR2CYSLTR1PKM | |
| SCHEMBL6156151 | 0.70 | APOBEC3G (0.35) | HPGDTDP1KMT2AKDM4EPKM | |
| SCHEMBL7533997 | 0.68 | ALDH1A1 (0.57) | HPGDTDP1MEN1KMT2ASLC6A3 | |
| SCHEMBL9505479 | 0.68 | — | — | |
| SCHEMBL9505472 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307449-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012235-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-02-14 | — | — | WO | disclosed |