Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 9/20 | 0.60 |
| ▸ | THRB | P10828 | 9/20 | 0.60 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140230 | 0.93 | THRA (0.53) | THRATHRBTTKMAPK8 | |
| SCHEMBL7135874 | 0.91 | THRA (0.73) | THRATHRB | |
| SCHEMBL7225729 | 0.88 | THRA (0.53) | THRATHRBTTKMAPK8 | |
| SCHEMBL7230331 | 0.87 | THRB (0.51) | THRATHRBTTKMAPK8 | |
| SCHEMBL7133369 | 0.85 | THRA (0.49) | THRATHRBTTKMAPK8 | |
| SCHEMBL7229224 | 0.85 | THRA (0.53) | THRATHRB | |
| SCHEMBL7138045 | 0.84 | THRA (0.48) | THRATHRBTTKMAPK8 | |
| SCHEMBL7130895 | 0.84 | THRA (0.66) | THRATHRB | |
| SCHEMBL7198479 | 0.82 | THRA (0.47) | THRATHRBTTKMAPK8 | |
| SCHEMBL7135882 | 0.81 | THRA (0.43) | THRATHRBTTKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608049-B2 | Indazoles | BAYER AKTIENGESELLSCHAFT (DE) | 2003-08-19 | — | — | US | disclosed |
| EP-1324987-A1 | INDAZOLES WITH THYROID HORMON LIKE ACTIVITY, A PROCESS FOR ITS PREPARATION AND ITS USE IN PHARMACEUTICAL COMPOSITIONS | Bayer Aktiengesellschaft (DE) | 2003-07-09 | — | — | EP | disclosed |
| US-20020193610-A1 | Indazoles | BAYER AKTIENGESELLSCHAFT (DE) | 2002-12-19 | — | — | US | disclosed |
| WO-2002022586-A1 | INDAZOLES HAVING AN ACTION SIMILAR TO THAT OF A THYROID HORMONE, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE IN MEDICAMENTS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193610-A1 | Indazoles | CYP3A43, CYP3A5, CYP3A4 | THRA 3910/4885THRB 4025/4885TTK 2934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.