Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 7/20 | 0.31 |
| ▸ | NOS3 | P29474 | 6/20 | 0.31 |
| ▸ | NOS1 | P29475 | 6/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27756123 | 0.78 | IMPDH2 (0.37) | TRPV4NOS2NOS3NOS1VCAM1 | |
| SCHEMBL28286565 | 0.76 | MAOA (0.41) | TRPV4MAOAMAOB | |
| SCHEMBL16824548 | 0.76 | MAOA (0.41) | TRPV4MAOAMAOB | |
| SCHEMBL9541780 | 0.73 | — | — | |
| SCHEMBL2639309 | 0.73 | MAOB (0.42) | TRPV4MAOAMAOB | |
| SCHEMBL7005991 | 0.72 | TRPV4 (0.57) | TRPV4MAOAMAOB | |
| Chloroform SCHEMBL28286554 | 0.72 | MAOA (0.38) | TRPV4MAOAMAOB | |
| SCHEMBL1434373 | 0.70 | CYP19A1 (0.46) | — | |
| SCHEMBL16824552 | 0.69 | MAOA (0.36) | TRPV4MAOAMAOB | |
| SCHEMBL8860681 | 0.68 | TSHR (0.48) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158983-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2003-05-21 | — | — | EP | disclosed |
| EP-1227800-A1 | OSMOTIC CONTROLLED RELEASE DRUG DELIVERY DEVICE | Merck & Co., Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1202747-A1 | SUSTAINED RELEASE DRUG DISPERSION DELIVERY DEVICE | Merck & Co., Inc. (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-1158983-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-1087770-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-11-14 | — | — | EP | disclosed |
| WO-2001045704-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-06-28 | — | — | WO | disclosed |
| WO-2001045707-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-06-28 | — | — | WO | disclosed |
| WO-2001032149-A1 | OSMOTIC CONTROLLED RELEASE DRUG DELIVERY DEVICE | MERCK & CO., INC. (US) | 2001-05-10 | — | — | WO | disclosed |
| EP-1087770-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-2001007437-A1 | CRYSTAL FORMS OF 1-(3-CHLOROPHENYL)-4-[1-(4-CYANOBENZYL)-5-IMIDAZOLYLMETHYL]-2-PIPERAZINONE | MERCK & CO., INC. (US) | 2001-02-01 | — | — | WO | disclosed |
| WO-2001005430-A1 | SUSTAINED RELEASE DRUG DISPERSION DELIVERY DEVICE | MERCK & CO., INC. (US) | 2001-01-25 | — | — | WO | disclosed |
| WO-2000059930-A1 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |
| WO-2000051612-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-09-08 | — | — | WO | disclosed |
| WO-2000025789-A1 | A METHOD OF TREATING ENDOMETRIOSIS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |
| WO-2000001691-A1 | PROCESS FOR MAKING FARNESYL-PROTEIN TRANSFERASE INHIBITORS | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |
| WO-2000001674-A1 | PROCESS FOR MAKING 1,5-DISUBSTITUTED IMIDAZOLES | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |
| WO-1999065494-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-12-23 | — | — | WO | disclosed |