Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 13/20 | 0.43 |
| ▸ | MMP13 | P45452 | 3/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137871 | 0.93 | MMP1 (0.49) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL7140995 | 0.83 | MMP1 (0.61) | MMP1MMP13ADAM17MMP2MMP9 | |
| Hydroxyamine SCHEMBL7339030 | 0.83 | MMP1 (0.40) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL7136841 | 0.75 | MMP1 (0.50) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL7135520 | 0.75 | MMP1 (0.49) | MMP1MMP13ADAM17MMP2MMP9 | |
| SCHEMBL7143794 | 0.74 | MMP1 (0.73) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL7137273 | 0.74 | MMP1 (0.55) | MMP1MMP13ADAM17MMP2MMP9 | |
| SCHEMBL7137286 | 0.74 | MMP1 (0.48) | MMP1MMP13ADAM17MMP2MMP9 | |
| SCHEMBL7142256 | 0.74 | MMP2 (0.41) | MMP1MMP13ADAM17MMP2MMP9 | |
| SCHEMBL7141637 | 0.73 | MMP1 (0.54) | MMP1MMP13ADAM17MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041072-B1 | Dioxocyclopentyl hydroxamic acids | PFIZER PROD INC (US) | 2003-07-16 | — | — | EP | disclosed |
| US-6214870-B1 | ANTIARTHRITIC AGENTS; ANTICANCER AGENTS | PFIZER INC | 2001-04-10 | — | — | US | disclosed |
| EP-1041072-A1 | Dioxocyclopentyl hydroxamic acids | Pfizer Products Inc. (US) | 2000-10-04 | — | — | EP | disclosed |