Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3246109 | 1.00 | ALDH1A1 (0.39) | ALDH1A1MAPTGPR35TET2NOTUM | |
| SCHEMBL29101734 | 0.82 | ALDH1A1 (0.36) | ALDH1A1MAPTGPR35TET2NOTUM | |
| SCHEMBL11032462 | 0.78 | ALDH1A1 (0.40) | ALDH1A1TET2KEAP1NFE2L2HCAR2 | |
| SCHEMBL4009654 | 0.78 | ALDH1A1 (0.35) | ALDH1A1MAPTTET2KEAP1NFE2L2 | |
| SCHEMBL2417309 | 0.76 | ALDH1A1 (0.39) | ALDH1A1MAPTGPR35TET2KEAP1 | |
| SCHEMBL11938107 | 0.76 | ALDH1A1 (0.36) | ALDH1A1MAPTGPR35TET2KEAP1 | |
| SCHEMBL8941587 | 0.76 | ALDH1A1 (0.39) | ALDH1A1TET2KEAP1NFE2L2HCAR2 | |
| SCHEMBL7868945 | 0.76 | ALDH1A1 (0.39) | ALDH1A1MAPTGPR35TET2KEAP1 | |
| SCHEMBL3230569 | 0.76 | GLO1 (0.45) | ALDH1A1MAPT | |
| SCHEMBL8828773 | 0.76 | GLO1 (0.45) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209791-B1 | Heterocyclic derivatives | MERCK SHARP & DOHME (NL) | 2014-01-22 | — | — | EP | disclosed |
| US-8129397-B2 | Substituted thieno[2,3-d]pyrimidines as AMPA modulators | MSD OSS B.V. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20090131455-A1 | HETEROCYCLIC DERIVATIVES | N.V. ORGANON | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131455-A1 | HETEROCYCLIC DERIVATIVES | GRIN2C, GRIK5, GRIN1 | ALDH1A1 398/4885MAPT 469/4885GPR35 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.