Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 7/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5407300 | 1.00 | KAT6A (0.42) | KAT6ASLC16A3CA2GSK3BKEAP1 | |
| SCHEMBL7141030 | 0.95 | KAT6A (0.46) | KAT6ACA2AKR1C3LMNASMN1; SMN2 | |
| SCHEMBL5399404 | 0.95 | KAT6A (0.46) | KAT6ACA2AKR1C3LMNASMN1; SMN2 | |
| SCHEMBL7140420 | 0.90 | PLAU (0.44) | KAT6ACA2LMNASMN1; SMN2PKM | |
| SCHEMBL7148694 | 0.85 | PKM (0.37) | KAT6ALMNASMN1; SMN2PKM | |
| SCHEMBL5422442 | 0.85 | PKM (0.37) | KAT6ALMNASMN1; SMN2PKM | |
| SCHEMBL7145132 | 0.79 | L3MBTL1 (0.37) | LMNAPKM | |
| SCHEMBL5409515 | 0.79 | L3MBTL1 (0.37) | LMNAPKM | |
| SCHEMBL5413603 | 0.75 | KAT6A (0.41) | KAT6ALMNASMN1; SMN2PKM | |
| SCHEMBL7146277 | 0.75 | ACACB (0.47) | KAT6ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |