Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | ACE | P12821 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5422442 | 1.00 | PKM (0.37) | PKMACEMMP1MMP7MMP12 | |
| SCHEMBL5399404 | 0.88 | KAT6A (0.46) | PKMCYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL7141030 | 0.88 | KAT6A (0.46) | PKMCYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5407300 | 0.85 | KAT6A (0.42) | PKMLMNASMN1; SMN2KAT6A | |
| SCHEMBL7137244 | 0.85 | KAT6A (0.42) | PKMLMNASMN1; SMN2KAT6A | |
| SCHEMBL5409515 | 0.85 | L3MBTL1 (0.37) | PKMACEMMP1MMP7MMP12 | |
| SCHEMBL7145132 | 0.85 | L3MBTL1 (0.37) | PKMACEMMP1MMP7MMP12 | |
| SCHEMBL7140420 | 0.85 | PLAU (0.44) | PKMACECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5413603 | 0.81 | KAT6A (0.41) | PKMACEMMP1MMP7MMP13 | |
| SCHEMBL5420093 | 0.81 | ACACB (0.47) | ACEMMP1MMP7MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |