Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141030 | 0.91 | KAT6A (0.46) | KAT6ALMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL5399404 | 0.91 | KAT6A (0.46) | KAT6ALMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL7137244 | 0.90 | KAT6A (0.42) | KAT6ALMNASMN1; SMN2PKMCA2 | |
| SCHEMBL5407300 | 0.90 | KAT6A (0.42) | KAT6ALMNASMN1; SMN2PKMCA2 | |
| SCHEMBL7148694 | 0.85 | PKM (0.37) | KAT6AALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL5422442 | 0.85 | PKM (0.37) | KAT6AALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL5409515 | 0.78 | L3MBTL1 (0.37) | MAPTLMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7145132 | 0.78 | L3MBTL1 (0.37) | MAPTLMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7146277 | 0.78 | ACACB (0.47) | KAT6AKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL5420093 | 0.78 | ACACB (0.47) | KAT6AKDM4EALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |