Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.51 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.48 |
| ▸ | RAF1 | P04049 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5361431 | 0.88 | METAP1 (0.54) | LRRK2PLK4MAP1LC3BSIRT1SIRT2 | |
| SCHEMBL5365589 | 0.85 | KMT2A (0.51) | PLK4MAP1LC3BSIRT1SIRT2SIRT3 | |
| SCHEMBL5362718 | 0.84 | MAP1LC3B (0.67) | LRRK2PLK4MAP1LC3BSIRT1SIRT2 | |
| SCHEMBL7134818 | 0.84 | MAP1LC3B (0.60) | LRRK2PLK4MAP1LC3BSIRT1SIRT2 | |
| SCHEMBL7134847 | 0.83 | KDM1A (0.58) | PLK4MAP1LC3BMEN1KMT2AKDM1A | |
| SCHEMBL7131372 | 0.82 | SIRT1 (0.48) | LRRK2PLK4MAP1LC3BSIRT1SIRT2 | |
| SCHEMBL7137977 | 0.82 | PLK4 (0.44) | LRRK2PLK4MAP1LC3BSIRT1SIRT2 | |
| SCHEMBL7134362 | 0.82 | SIRT2 (0.51) | LRRK2PLK4MAP1LC3BSIRT1SIRT2 | |
| SCHEMBL5361680 | 0.81 | SIRT2 (0.54) | PLK4MAP1LC3BSIRT1SIRT2SIRT3 | |
| SCHEMBL7136821 | 0.81 | LRRK2 (0.51) | LRRK2PLK4SIRT1SIRT2SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |