Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 4/20 | 0.54 |
| ▸ | MMP9 | P14780 | 4/20 | 0.54 |
| ▸ | MMP1 | P03956 | 3/20 | 0.54 |
| ▸ | MMP13 | P45452 | 3/20 | 0.54 |
| ▸ | MMP3 | P08254 | 2/20 | 0.54 |
| ▸ | MMP7 | P09237 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25269775 | 1.00 | TSHR (0.58) | TSHRHSD17B10HTTALDH1A1KDM4E | |
| SCHEMBL7889040 | 1.00 | TSHR (0.58) | TSHRHSD17B10HTTALDH1A1KDM4E | |
| SCHEMBL8446641 | 0.91 | MMP9 (0.64) | TSHRHSD17B10HTTALDH1A1KDM4E | |
| SCHEMBL6799581 | 0.91 | TSHR (0.51) | TSHRHSD17B10HTTALDH1A1KDM4E | |
| SCHEMBL19404003 | 0.86 | HTT (0.54) | TSHRHSD17B10HTTALDH1A1KDM4E | |
| SCHEMBL29541363 | 0.85 | HSD17B10 (0.60) | TSHRHSD17B10HTTALDH1A1KDM4E | |
| SCHEMBL6329698 | 0.85 | HSD17B10 (0.60) | TSHRHSD17B10HTTALDH1A1KDM4E | |
| SCHEMBL6329696 | 0.85 | HSD17B10 (0.60) | TSHRHSD17B10HTTALDH1A1KDM4E | |
| SCHEMBL11578980 | 0.85 | ADAMTS4 (0.59) | TSHRHSD17B10HTTALDH1A1HPGD | |
| SCHEMBL1903552 | 0.85 | SLC1A3 (0.56) | TSHRHSD17B10HTTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250066318-A1 | HETEROCYCLIC COMPOUNDS AS DYRK1A INHIBITORS | PROTHENA BIOSCIENCES INC | 2025-02-27 | — | — | US | disclosed |
| CN-118843626-A | Heterocyclic compounds as DYRK1A inhibitors | 普罗塞纳生物科学有限公司 | 2024-10-25 | — | — | CN | disclosed |
| EP-4444421-A2 | HETEROCYCLIC COMPOUNDS AS DYRK1A INHIBITORS | Prothena Biosciences Limited (IE) | 2024-10-16 | — | — | EP | disclosed |
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |
| WO-2023107714-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |
| EP-2246331-A1 | NR2B-selective NMDA-receptor antagonists | Westfälische Wilhelms-Universität Münster (DE) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010122134-A1 | NR2B-SELECTIVE NMDA-RECEPTOR ANTAGONISTS | Westfälische Wilhelms Universität Münster (DE) | 2010-10-28 | — | — | WO | disclosed |
| US-6509506-B1 | Asymmetric aminohydroxylation of olefins using osmium catalyst; oxidation | THE SCRIPPS RESEARCH INSTITUTE | 2003-01-21 | — | — | US | disclosed |
| US-5994583-A | Two step synthesis of D- and L- α-amino acids and D- and L- α-amino-aldehydes | THE SCRIPPS RESEARCH INSTITUTE (US) | 1999-11-30 | — | — | US | disclosed |
| US-5859281-A | Catalytic asymmetric aminohydroxylation of olefins with sulfonamides | THE SCRIPPS RESEARCH INSTITUTE (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1997044316-A9 | CATALYTIC ASYMMETRIC AMINOHYDROXYLATION OF OLEFINS WITH SULFONAMIDES | — | 1998-04-09 | — | — | WO | disclosed |
| WO-1997044316-A1 | CATALYTIC ASYMMETRIC AMINOHYDROXYLATION OF OLEFINS WITH SULFONAMIDES | THE SCRIPPS RESEARCH INSTITUTE (US) | 1997-11-27 | — | — | WO | disclosed |
| WO-1997044312-A1 | TWO STEP SYNTHESIS OF D- AND L- α-AMINO ACIDS AND D- AND L- α-AMINO ALDEHYDES | THE SCRIPPS RESEARCH INSTITUTE (US) | 1997-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066318-A1 | HETEROCYCLIC COMPOUNDS AS DYRK1A INHIBITORS | DYRK1A, DYRK2, DYRK1B | TSHR 1011/4885HSD17B10 2827/4885HTT 257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.