Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 10/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | RARA | P10276 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137830 | 0.84 | RARA (0.38) | MAPTLMNAHTTBLMBACE1 | |
| SCHEMBL7143649 | 0.83 | BACE1 (0.31) | BACE1 | |
| SCHEMBL3426809 | 0.81 | LMNA (0.39) | MAPTLMNAHTTBLMBACE1 | |
| SCHEMBL7141763 | 0.81 | LMNA (0.36) | MAPTLMNAHTTBLMBACE1 | |
| SCHEMBL7141442 | 0.80 | RARA (0.32) | RARARARBRARGAKR1B1 | |
| SCHEMBL7143121 | 0.79 | KMT2A (0.39) | LMNAHTTKMT2A | |
| SCHEMBL3429359 | 0.78 | ALDH1A1 (0.38) | MAPTLMNAHTTBLMBACE1 | |
| SCHEMBL2599701 | 0.77 | RARA (0.48) | MAPTLMNAHTTBLMBACE1 | |
| SCHEMBL29616597 | 0.77 | RARA (0.48) | MAPTLMNAHTTBLMBACE1 | |
| SCHEMBL7142829 | 0.77 | BACE1 (0.31) | BACE1RARARARBRARGAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151144-C | Benzopyrans and benzothiopyrans as RAR selective retinoid agonists | - | 2004-05-26 | — | — | CN | disclosed |
| EP-1212316-B1 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | HOFFMANN LA ROCHE (CH) | 2003-10-15 | — | — | EP | disclosed |
| US-6479670-B1 | Selective retinoid acid receptor agonists | HOFFMANN-LA ROCHE INC. | 2002-11-12 | — | — | US | disclosed |
| CN-1370156-A | Benzopyrans and benzothiopyrans as RAR selective retinoid agonists | HOFFMANN LA ROCHE (CH) | 2002-09-18 | — | — | CN | disclosed |
| EP-1212316-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014360-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMAN-LA ROCHE AG (CH) | 2001-03-01 | — | — | WO | disclosed |