Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 3/20 | 0.32 |
| ▸ | BIRC2 | Q13490 | 3/20 | 0.32 |
| ▸ | BACE1 | P56817 | 5/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136215 | 0.85 | LMNA (0.33) | LMNAMAPTHTTBLMMAP3K14 | |
| SCHEMBL7141712 | 0.83 | LMNA (0.38) | LMNAMAPTHTTBLMMAP3K14 | |
| SCHEMBL7140485 | 0.81 | MAPT (0.38) | LMNAMAPTHTTBLMBACE1 | |
| SCHEMBL7139476 | 0.81 | MAP3K14 (0.30) | MAP3K14 | |
| SCHEMBL7143649 | 0.81 | BACE1 (0.31) | BACE1 | |
| SCHEMBL7146611 | 0.80 | LMNA (0.33) | LMNAMAPTHTTBLMMAP3K14 | |
| SCHEMBL15023284 | 0.78 | LMNA (0.43) | LMNAMAPTHTTBLMMAP3K14 | |
| SCHEMBL7139191 | 0.78 | — | — | |
| SCHEMBL7144498 | 0.74 | RARB (0.50) | — | |
| SCHEMBL7140832 | 0.74 | RARA (0.50) | LMNAMAPTBLMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212316-B1 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | HOFFMANN LA ROCHE (CH) | 2003-10-15 | — | — | EP | disclosed |
| US-6479670-B1 | Selective retinoid acid receptor agonists | HOFFMANN-LA ROCHE INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1212316-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014360-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMAN-LA ROCHE AG (CH) | 2001-03-01 | — | — | WO | disclosed |