SCHEMBL7140533

SCHEMBL7140533

COc1cc(F)c2nccc(C(Br)C=O)c2c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.35
MAPK1 P28482 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
ACVR1 Q04771 1/20 0.35
NSD2 O96028 2/20 0.32
CASP6 P55212 2/20 0.32
PDE2A O00408 1/20 0.32
PDE10A Q9Y233 1/20 0.32
CHRM2 P08172 1/20 0.32
CHRM1 P11229 1/20 0.32
CHRM3 P20309 1/20 0.32
SLC40A1 Q9NP59 1/20 0.32
LMNA P02545 1/20 0.32
HSP90AA1 P07900 1/20 0.31
HSP90AB1 P08238 1/20 0.31
NFE2L2 Q16236 2/20 0.31
CCR1 P32246 2/20 0.31
CCR5 P51681 2/20 0.31
CCR8 P51685 2/20 0.31
CYP1A1 P04798 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3929993 0.77 ROCK2 (0.35) ACVR1NSD2CASP6PDE10AHSP90AA1
SCHEMBL3375976 0.77 CCR1 (0.49) KDM4EMAPK1NPSR1ACVR1NSD2
SCHEMBL3375901 0.75 CCR1 (0.38) KDM4EACVR1NSD2CASP6PDE2A
SCHEMBL5506908 0.73 SLC10A1 (0.38) ACVR1PDE2APDE10ALMNA
SCHEMBL6447631 0.73 CHRM2 (0.41) CHRM2CHRM1CHRM3LMNACYP1A1
SCHEMBL20551265 0.73 CHRM2 (0.41) CHRM2CHRM1CHRM3LMNACYP1A1
SCHEMBL4279169 0.72 NOS3 (0.43) KDM4EACVR1NSD2CASP6PDE2A
SCHEMBL2923376 0.72 NOS3 (0.40) KDM4EMAPK1NPSR1ACVR1NSD2
SCHEMBL18544288 0.72 CCR1 (0.38) KDM4EACVR1NSD2CASP6PDE2A
SCHEMBL3403559 0.72 NSD2 (0.35) KDM4EMAPK1NSD2CASP6LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1305308-A1 AMINOPIPERIDINE QUINOLINES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY SMITHKLINE BEECHAM PLC (GB) 2003-05-02 EP disclosed
WO-2002008224-A1 AMINOPIPERIDINE QUINOLINES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY SMITHKLINE BEECHAM P.L.C. (GB) 2002-01-31 WO disclosed