Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14189067 | 0.82 | HTR6 (0.69) | HTR6ALDH1A1GAAKDM4EPKM | |
| SCHEMBL10040111 | 0.81 | HTR6 (1.00) | HTR6ALDH1A1GAAKDM4EPKM | |
| SCHEMBL14372093 | 0.79 | HTR6 (1.00) | HTR6ALDH1A1GAAKDM4EHPGD | |
| SCHEMBL30714169 | 0.76 | PTGES2 (0.43) | HTR6 | |
| SCHEMBL16810 | 0.75 | HSD11B1 (0.57) | HTR6GAAPOLBGFER | |
| SCHEMBL2350373 | 0.75 | AKR1B1 (0.51) | HTR6ALDH1A1GAAPKMPOLB | |
| SCHEMBL229081 | 0.74 | HTR6 (0.48) | HTR6ALDH1A1GAAKDM4EPOLB | |
| SCHEMBL226516 | 0.74 | HTR6 (0.48) | HTR6ALDH1A1GAAKDM4EPOLB | |
| Hydrochloric Acid SCHEMBL28072887 | 0.73 | GLA (0.39) | HTR6ALDH1A1GAA | |
| SCHEMBL19584820 | 0.73 | MEN1 (0.53) | ALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1148356-C | Benzosulfone derivatives | - | 2004-05-05 | — | — | CN | disclosed |
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | disclosed |
| CN-1231287-A | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 1999-10-13 | — | — | CN | disclosed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | disclosed |