Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 3/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143569 | 0.77 | USP2 (0.34) | OPRK1ALDH1A1MEN1KMT2ACYP2D6 | |
| SCHEMBL6634552 | 0.77 | ADRA2B (0.44) | HTR2ASLC6A2SLC6A4SLC6A3OPRK1 | |
| SCHEMBL2645309 | 0.75 | ALDH1A1 (0.49) | HTR2ASLC6A2SLC6A4SLC6A3OPRK1 | |
| SCHEMBL28427943 | 0.73 | ESR1 (0.42) | ALDH1A1LMNACCR5TP53 | |
| SCHEMBL12126358 | 0.73 | HTR2A (0.45) | HTR2ASLC6A2SLC6A4SLC6A3OPRK1 | |
| SCHEMBL1041217 | 0.73 | TSHR (0.54) | HTR2ASLC6A2SLC6A4SLC6A3OPRK1 | |
| SCHEMBL7140660 | 0.72 | CHRNB2 (0.50) | TSHRALDH1A1LMNAMAOBCYP2D6 | |
| Water SCHEMBL27613449 | 0.70 | HTR2A (0.46) | HTR2ASLC6A2SLC6A4SLC6A3OPRK1 | |
| SCHEMBL13452589 | 0.70 | ADRA2B (0.50) | HTR2ASLC6A2SLC6A4SLC6A3OPRK1 | |
| SCHEMBL14017766 | 0.70 | ADRA2B (0.50) | HTR2ASLC6A2SLC6A4SLC6A3OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515133-B1 | Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. | NEUROGEN CORPORATION | 2003-02-04 | — | — | US | claimed |
| US-6121260-A | Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives | NEUROGEN CORPORATION (US) | 2000-09-19 | — | — | US | claimed |