SCHEMBL2645309

SCHEMBL2645309

CN(Cc1c[c]ccc1)Cc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.49
SMN1; SMN2 Q16637 3/20 0.49
KDM4E B2RXH2 3/20 0.49
CARM1 Q86X55 1/20 0.48
PRMT6 Q96LA8 1/20 0.48
PRMT8 Q9NR22 1/20 0.48
TSHR P16473 2/20 0.48
LMNA P02545 3/20 0.47
USP2 O75604 1/20 0.47
CYP3A4 P08684 1/20 0.47
MAOA P21397 1/20 0.47
MAOB P27338 1/20 0.47
PYCR1 P32322 1/20 0.47
BLM P54132 1/20 0.46
AOC3 Q16853 1/20 0.45
SIGMAR1 Q99720 1/20 0.44
GAA P10253 2/20 0.44
MAPT P10636 1/20 0.44
ADRA2B P18089 1/20 0.43
ADRA2C P18825 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7140660 0.85 CHRNB2 (0.50) ALDH1A1SMN1; SMN2KDM4ECARM1PRMT6
SCHEMBL1041217 0.82 TSHR (0.54) ALDH1A1TSHRAOC3ADRA2BADRA2C
SCHEMBL2645780 0.82 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2KDM4ECARM1PRMT6
SCHEMBL6634828 0.81 CARM1 (0.42) ALDH1A1SMN1; SMN2KDM4ECARM1PRMT6
Dibemethine SCHEMBL10542007 0.81 ALDH1A1 (0.70) ALDH1A1SMN1; SMN2KDM4ECARM1PRMT6
Dibemethine SCHEMBL276863 0.81 ALDH1A1 (0.70) ALDH1A1SMN1; SMN2KDM4ECARM1PRMT6
Dibemethine SCHEMBL2139708 0.79 ALDH1A1 (0.67) ALDH1A1SMN1; SMN2KDM4ECARM1PRMT6
SCHEMBL6634552 0.78 ADRA2B (0.44) ALDH1A1KDM4ETSHRMAOAMAOB
SCHEMBL921192 0.78 NR1H2 (0.46) ALDH1A1CARM1PRMT6PRMT8TSHR
SCHEMBL27947941 0.78 CARM1 (0.50) CARM1PRMT6PRMT8LMNAMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0871444-A4 2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE MERCK & CO INC (US) 1999-01-13 EP claimed
US-5837719-A USEFUL FOR TREATING CYTOKINE MEDIATED DISEASES, INFLAMMATION,SHOCK, ARTHRITIS, RESPIRATORY DISORDERS, THROMBOSIS, VIRAL INFECTION, GASTROINTESTINAL DISORDERS MERCK & CO., INC. (US) 1998-11-17 US claimed
EP-0871444-A1 2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE Merck & Co., Inc. (US) 1998-10-21 EP claimed
WO-1997016441-A1 SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE MERCK & CO., INC. (US) 1997-05-09 WO claimed
WO-1997005878-A1 2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE MERCK & CO., INC. (US) 1997-02-20 WO claimed
EP-0871444-A4 2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE MERCK & CO INC (US) 1999-01-13 EP disclosed
US-5837719-A USEFUL FOR TREATING CYTOKINE MEDIATED DISEASES, INFLAMMATION,SHOCK, ARTHRITIS, RESPIRATORY DISORDERS, THROMBOSIS, VIRAL INFECTION, GASTROINTESTINAL DISORDERS MERCK & CO., INC. (US) 1998-11-17 US disclosed
EP-0871444-A1 2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE Merck & Co., Inc. (US) 1998-10-21 EP disclosed
WO-1997016441-A1 SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE MERCK & CO., INC. (US) 1997-05-09 WO disclosed
WO-1997005878-A1 2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE MERCK & CO., INC. (US) 1997-02-20 WO disclosed