Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 5/20 | 0.60 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.48 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.48 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.48 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30775369 | 0.91 | KMO (0.65) | KMOSYKKDM4CSRD5A2MEN1 | |
| SCHEMBL27910329 | 0.87 | SYK (0.53) | KMOSYKKDM4EAURKAMRGPRX4 | |
| Nitrous Acid SCHEMBL29163822 | 0.86 | KMO (0.60) | KMOSYKKDM4CSRD5A2MEN1 | |
| SCHEMBL4900014 | 0.85 | KMO (0.72) | KMOSYKKDM4CSRD5A2MEN1 | |
| SCHEMBL30393660 | 0.82 | RXRA (0.63) | KMOSRD5A2MEN1KMT2AKDM4E | |
| SCHEMBL15498897 | 0.82 | KMO (0.49) | KMOKDM4EALDH1A1 | |
| SCHEMBL177461 | 0.82 | RXRA (0.63) | KMOSRD5A2MEN1KMT2AKDM4E | |
| SCHEMBL2625107 | 0.82 | ASIC3 (0.53) | KMOKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL18356745 | 0.81 | HSD17B1 (0.52) | KMOSYK | |
| SCHEMBL4901517 | 0.81 | KMO (0.60) | KMOSYKKDM4CMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318978-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | Abbott Laboratories (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024636-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2002-03-28 | — | — | WO | disclosed |