Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.37 |
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | LATS1 | O95835 | 2/20 | 0.36 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27550360 | 0.81 | LATS1 (0.39) | NOS1NOS3NOS2LATS1LATS2 | |
| SCHEMBL5400443 | 0.80 | PGR (0.44) | CRHR1EGLN1 | |
| SCHEMBL27550359 | 0.77 | PTGS2 (0.36) | LATS1LATS2CRHR1EGLN1DGAT1 | |
| SCHEMBL5409128 | 0.76 | MAP4K4 (0.41) | NOS1NOS3NOS2CRHR1 | |
| SCHEMBL7146306 | 0.74 | NCF1 (0.53) | EGLN1 | |
| SCHEMBL5419165 | 0.73 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL7137892 | 0.73 | NCF1 (0.55) | EGLN1 | |
| SCHEMBL5420608 | 0.73 | CRHR1 (0.44) | LATS1LATS2CRHR1 | |
| SCHEMBL7146671 | 0.71 | NCF1 (0.57) | — | |
| SCHEMBL14359489 | 0.70 | NPSR1 (0.48) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318981-A2 | QUINOLINE AND QUINAZOLINE DERIVATIVES AS LIGANDS FOR THE NEUROPEPTIDE Y RECEPTOR | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002020488-A2 | QUINOLINE AND QUINAZOLINE DERIVATIVES AS LIGANDS FOR THE NEUROPEPTIDE Y RECEPTOR | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-14 | — | — | WO | disclosed |