Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6282444 | 0.98 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1APPGAAHCAR3 | |
| SCHEMBL7147666 | 0.90 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1APPGAAHCAR3 | |
| Bromide SCHEMBL6546257 | 0.89 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1APPGAAHCAR3 | |
| SCHEMBL7149156 | 0.87 | CYP17A1 (0.49) | SMN1; SMN2ALDH1A1APPGAAHCAR3 | |
| SCHEMBL7142799 | 0.86 | NAMPT (0.49) | SMN1; SMN2ALDH1A1GAALMNATBXAS1 | |
| SCHEMBL7149214 | 0.86 | POLB (0.51) | SMN1; SMN2ALDH1A1GAAEPHX2LMNA | |
| Bromide SCHEMBL6279795 | 0.86 | CYP17A1 (0.48) | SMN1; SMN2ALDH1A1APPGAAHCAR3 | |
| SCHEMBL7144713 | 0.86 | CYP19A1 (0.53) | SMN1; SMN2ALDH1A1GAAHTTL3MBTL1 | |
| Bromide SCHEMBL6284312 | 0.84 | CYP19A1 (0.51) | SMN1; SMN2ALDH1A1GAAHTTL3MBTL1 | |
| Bromide SCHEMBL6283209 | 0.84 | POLB (0.50) | SMN1; SMN2ALDH1A1GAAEPHX2KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620825-B1 | 1,3-Azole compound substituted by pyridyl; administering as antiasthmatic, antiinflammatory or antiallergen agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-16 | — | — | US | disclosed |
| US-6436966-B1 | Adenosine A3 receptor antagonists | TAKEDA CHEMICAL IND., LTD. (JP) | 2002-08-20 | — | — | US | disclosed |
| EP-0149884-B1 | 5-PYRIDYL-1,3-THIAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-12-16 | — | — | EP | disclosed |
| US-4612321-A | 5-pyridyl-1,3-thiazole derivatives | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 1986-09-16 | — | — | US | disclosed |
| EP-0149884-A2 | 5-Pyridyl-1,3-thiazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1985-07-31 | — | — | EP | disclosed |
| US-3940486-A | Imidazole derivatives in the treatment of pain | CIBA-GEIGY CORPORATION (US) | 1976-02-24 | — | — | US | disclosed |