Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.55 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142813 | 0.93 | HTR2A (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7141347 | 0.91 | CHRM4 (0.52) | HTTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7141098 | 0.90 | OPRM1 (0.53) | OPRM1CHRM2CHRM3ALDH1A1BACE1 | |
| SCHEMBL1682312 | 0.82 | HTT (0.54) | HTTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2336394 | 0.81 | HTT (0.53) | HTTCHRM2CHRM3ALDH1A1CYP2D6 | |
| SCHEMBL7140154 | 0.81 | HTT (0.58) | HTTOPRM1CHRM2CHRM3ALDH1A1 | |
| SCHEMBL14045066 | 0.81 | HTR6 (0.48) | HTTOPRM1CHRM2CHRM3ALDH1A1 | |
| SCHEMBL7146866 | 0.80 | LMNA (0.54) | HTTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL16757144 | 0.76 | KMT2A (0.69) | OPRM1CHRM2CHRM3ALDH1A1BACE1 | |
| SCHEMBL2337985 | 0.75 | ALDH1A1 (0.52) | HTTPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030176461-A1 | Aminopiperidines | NPS ALLELIX CORP. (CANADA CORPORATION) (CA) | 2003-09-18 | — | — | US | claimed |
| EP-1296950-A2 | AMINOPIPERIDINES FOR USE AS GLYT-1 INHIBITORS | NPS Allelix Corp. (CA) | 2003-04-02 | — | — | EP | claimed |
| WO-2001081308-A2 | AMINOPIPERIDINES FOR USE AS GLYT-1 INHIBITORS | NPS ALLELIX CORP. (CA) | 2001-11-01 | — | — | WO | claimed |
| US-20030176461-A1 | Aminopiperidines | NPS ALLELIX CORP. (CANADA CORPORATION) (CA) | 2003-09-18 | — | — | US | disclosed |
| EP-1296950-A2 | AMINOPIPERIDINES FOR USE AS GLYT-1 INHIBITORS | NPS Allelix Corp. (CA) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001081308-A2 | AMINOPIPERIDINES FOR USE AS GLYT-1 INHIBITORS | NPS ALLELIX CORP. (CA) | 2001-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176461-A1 | Aminopiperidines | SLC1A2, SLC6A4, SLC1A1 | HTT 315/4885PSEN1 154/4885PSEN2 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.