Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143079 | 0.81 | CPT2 (0.47) | HTR2CPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6202628 | 0.75 | HTR2A (0.51) | DCUN1D1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL7143386 | 0.75 | POLB (0.41) | HTR2CPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7141674 | 0.74 | POLB (0.38) | OPRM1POLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7149001 | 0.73 | POLB (0.41) | HTR2CPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3811903 | 0.72 | DCUN1D1 (0.58) | DCUN1D1SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL20315235 | 0.72 | PSEN1 (0.45) | HTR2CPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7143693 | 0.72 | SMN1; SMN2 (0.45) | HTR2CPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4198203 | 0.71 | OPRM1 (0.62) | DCUN1D1SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL7138322 | 0.71 | POLB (0.42) | HTR2CPOLBNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303485-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006222-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |