Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.59 |
| ▸ | DRD2 | P14416 | 10/20 | 0.59 |
| ▸ | HTR7 | P34969 | 5/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | HTR1A | P08908 | 4/20 | 0.59 |
| ▸ | HTR2C | P28335 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.59 |
| ▸ | DRD1 | P21728 | 3/20 | 0.59 |
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | DRD5 | P21918 | 3/20 | 0.59 |
| ▸ | HTR1B | P28222 | 3/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.59 |
| ▸ | HRH1 | P35367 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7147314 | 0.88 | CYP2D6 (0.54) | HTR2ADRD2HTR7CYP2D6TSHR | |
| SCHEMBL7150372 | 0.84 | HTR2A (0.47) | HTR2ADRD2HTR7CYP2D6TSHR | |
| SCHEMBL7145886 | 0.81 | HTR2A (0.47) | HTR2ADRD2HTR7CYP2D6TSHR | |
| SCHEMBL7140214 | 0.79 | HTR2A (0.61) | HTR2ADRD2HTR7CYP2D6TSHR | |
| SCHEMBL10919317 | 0.79 | HTR2C (0.73) | HTR2ADRD2HTR7CYP2D6TSHR | |
| SCHEMBL15999621 | 0.79 | HTR1A (0.65) | HTR2ADRD2HTR7CYP2D6TSHR | |
| SCHEMBL9276925 | 0.77 | DRD2 (0.56) | HTR2ADRD2HTR7CYP2D6TSHR | |
| SCHEMBL10924461 | 0.77 | SLC6A4 (0.55) | HTR2ADRD2HTR7CYP2D6TSHR | |
| SCHEMBL7283740 | 0.77 | DRD2 (0.66) | HTR2ADRD2HTR7CYP2D6TSHR | |
| SCHEMBL7699932 | 0.77 | DRD2 (0.55) | HTR2ADRD2HTR7CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808313-B1 | ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-08-13 | — | — | EP | claimed |
| EP-0808313-A1 | ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-11-26 | — | — | EP | claimed |
| WO-1996023784-A1 | ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-08-08 | — | — | WO | claimed |
| EP-0808313-B1 | ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-08-13 | — | — | EP | disclosed |