Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | DGKA | P23743 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 7/20 | 0.53 |
| ▸ | HTR1A | P08908 | 7/20 | 0.53 |
| ▸ | HTR2A | P28223 | 7/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142123 | 0.88 | HTR2A (0.59) | CYP2D6MAPTTSHRTDP1ALDH1A1 | |
| SCHEMBL7150338 | 0.84 | DRD2 (0.51) | CYP2D6MAPTTSHRTDP1ALDH1A1 | |
| SCHEMBL7149529 | 0.84 | DRD2 (0.53) | CYP2D6MAPTTSHRTDP1ALDH1A1 | |
| SCHEMBL6617444 | 0.80 | ALDH1A1 (0.55) | CYP2D6MAPTTSHRTDP1ALDH1A1 | |
| SCHEMBL7145335 | 0.80 | DRD2 (0.52) | CYP2D6MAPTTSHRCYP2C9KDM4E | |
| SCHEMBL7699102 | 0.77 | DRD2 (0.54) | CYP2D6MAPTTSHRTDP1ALDH1A1 | |
| SCHEMBL12786167 | 0.76 | ALDH1A1 (0.56) | CYP2D6MAPTTSHRTDP1ALDH1A1 | |
| SCHEMBL10944718 | 0.75 | ALDH1A1 (0.51) | CYP2D6MAPTTSHRTDP1ALDH1A1 | |
| SCHEMBL10922663 | 0.75 | CYP2D6 (0.51) | CYP2D6MAPTTSHRTDP1ALDH1A1 | |
| SCHEMBL15999621 | 0.74 | HTR1A (0.65) | CYP2D6MAPTTSHRTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808313-B1 | ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-08-13 | — | — | EP | disclosed |