Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6265289 | 0.85 | ERCC5 (0.46) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL7770355 | 0.85 | ERCC5 (0.46) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL7770353 | 0.85 | ERCC5 (0.46) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL8576220 | 0.79 | HPGD (0.36) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL3122885 | 0.78 | LMNA (0.52) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL4787172 | 0.78 | LMNA (0.52) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL3122880 | 0.78 | LMNA (0.52) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL712292 | 0.75 | PTGER4 (0.47) | HPGDKMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL8972816 | 0.74 | AKR1C2 (0.58) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL9333403 | 0.74 | PPARG (0.39) | ALDH1A1HSD17B10KMT2AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124761-B2 | Coupling of methyl (E)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate with 2-cyanophenyl in DMF with 2 mol % DABCO; significantly smaller amounts of this relatively expensive catalyst may be used without compromising the yield | SYNGENTA LIMITED (GB) | 2012-02-28 | — | — | US | disclosed |
| EP-2308825-A1 | Process for the preparation of an intermediate for azoxystrobin | Syngenta Limited (GB) | 2011-04-13 | — | — | EP | disclosed |